Layer-by-Layer Self-Assembly of Polyelectrolytes on Superparamagnetic Nanoparticle Surfaces

Abstract

Designing and manufacturing multifunctional nanoparticles (NPs) are of considerable interest for both academic and industrial research. Among NPs used in this field, iron oxide NPs show low toxicity compared to metallic ones and are thus of high interest for biomedical applications. In this work, superparamagnetic Fe 3−δ O 4 -based core/shell NPs were successfully prepared and characterized by the combination of different techniques, and their physical properties were investigated. We demonstrate the efficiency of the layer-by-layer process to graft polyelectrolytes on the surface of iron oxide NPs. The influence of the polyelectrolyte chain configuration on the magnetic properties of the Fe 3−δ O 4 /polymer core/shell NPs was enlightened. The simple and fast process described in this work is efficient for the grafting of polyelectrolytes from surfaces, and thus, derived Fe 3−δ O 4 NPs display both the physical properties of the core and of the macromolecular shell. Finally, the cytotoxicity toward the human THP-1 monocytic cell line of the core/shell NPs was assessed. The results showed that the polymer-capped Fe 3−δ O 4 NPs exhibited almost no toxicity after 24 h of exposure at concentrations up to 25 μg mL −1 . Our results show that these smart superparamagnetic nanocarriers with stealth properties are promising for applications in multimodal cancer therapy, including drug delivery.

A decade of developing applications exploiting the properties of polyelectrolyte multilayer capsules

“…Red blood cells were some of the first cells for LbL self-assembly. 285,286 The choice of a modification shell is determined mostly by properties of the modified biological system and by a possible need for keeping it viable during and after the encapsulation. Immunological or physical protection for cells is one obvious benefit that microcapsule structures introduce.…”

Current Status and Advancement of Nanomaterials within Polymeric Membranes for Water Purification

“…81,90,94 Membranes produced via this method have enhanced mechanical stability since the nanomaterials incorporated into the polymers improve their strength and durability, making them suitable for use in harsh environments such as high-pressure and high-temperature applications. 94,95 3.4. Sol−Gel Process.…”

“…Layer-by-layer assembly is a bottom-up technique used to develop membranes by subsequently depositing alternating layers of oppositely charged macromolecules (mainly polyelectrolytes) onto a substrate and washing them after every step, resulting in the formation of a dense, uniform, and well-defined membrane. ,, Membranes produced via this method have enhanced mechanical stability since the nanomaterials incorporated into the polymers improve their strength and durability, making them suitable for use in harsh environments such as high-pressure and high-temperature applications. , …”

The Effect of Copolymer-Based Nanoparticle Composition (MEO2MA-OEGMA) on the Release Profile of Doxorubicin In Vitro

“…The synthesis of superparamagnetic Fe 3−δ O 4 NPs (SPIONs) was carried out by coprecipitation [23]. A mixture of FeCl 3 •6H 2 O (6 mmol; 1.622 g) and FeSO 4 •7H 2 O (5 mmol; 1.39 g) was dissolved in forty mL of water in a three-neck flask.…”