To improve the real-time performance and the target adaptability of penetration fuze detonation control systems, and to enhance the system fusion processing capability for multi-sensor information, this paper uses a modular design concept to construct a miniaturized (ø38[Formula: see text]mm[Formula: see text]×[Formula: see text]4[Formula: see text]mm) fuze detonation control system that is capable of real-time processing of data from multiple information sources. The core component of this system is the GD32E230 microcontroller, which features a high dominant frequency and low power consumption. This device is integrated with a ferroelectric memory and signal processing circuits that match the sensors. To address the issue of unclear traditional acceleration signal penetration and the difficulties associated with the identification of these signals, the approach in this paper improves feature recognition accuracy through rapid acquisition and fusion of multiple types of sensor output signal, and self-adaptive identification of multilayered targets and single-layer thick targets is achieved. During the programming of the embedded system, the hardware register is operated directly, the instruction execution sequence is optimized, and the program execution efficiency is improved by using the function characteristic that some microcontroller unit peripherals do not occupy the central processing unit when working, thus allowing the intended purpose of improving the system’s real-time performance to be achieved. A semi-physical simulation method is then used to verify the performance of the penetration fuze detonation control system. The results obtained show that the system has 100%-layer counting accuracy for multilayered targets and a relative error of less than 1% for the calculated residual velocities of single-layer thick targets, thus validating the effectiveness of the system.