Layer-specific sensory processing impairment in the primary somatosensory cortex after motor cortex infarction

Abstract

Stroke (Ischemic Stroke) 14 15 Number of words in the main text (not including Abstract, Methods, References and figure legends) : 16 word count，1988 words 17Abstract (max, 200 words) 1 2 Primary motor cortex (M1) infarction occasionally causes sensory impairment. Because sensory 3 signal plays an important role in motor control, sensory impairment compromises recovery and 4 rehabilitation from motor disability. Despite the importance of sensory-motor integration for 5 rehabilitation after M1 infarction, the neural mechanism of the sensory impairment is poorly 6 understood. We show that the sensory processing in the primary somatosensory cortex (S1) was 7 impaired in the acute phase of M1 infarction and recovered in a layer-specific manner in the subacute 8 phase. This layer dependent recovery process and the anatomical connection pattern from M1 to S1 9 suggested the functional connectivity from M1 to S1 plays a key role in the impairment of sensory 10 processing in S1. The simulation study demonstrated that the loss of inhibition from M1 to S1 in the 11 acute phase of M1 infarction could cause the sensory processing impairment in S1, and the 12 complementation of inhibition could recover the temporal coding. Taken together, we revealed how 13 focal stroke of M1 alters cortical network activity of sensory processing, in which inhibitory input 14 from M1 to S1 may be involved. 15 16 17