The sitting position is very common in everyday life and therefore any garment should be comfortable in that positon. It is especially important for those who are disabled and are confined to a sitting position throughout life. These include paraplegics whose restricted movements are due to paralysis of the lower limbs and restrict them to a wheelchair. Garments for a sitting position should meet certain particular needs like the body dimensions and postures of each individual. Design considerations should provide ergonomic comfort in a sitting position and include functional requirements due to limitations of strength and mobility in such a way that they do not cause additional health problems to paraplegics, e.g. skin irritations, pressure sores, obstruction of the blood flow etc., but rather to improve the quality of life for paraplegics. Today, the development of garments is practically impossible to imagine without the assistance of 3D CAD systems for the virtual prototyping of garments, which usually provide only the 3D body models in a standing position. The aim of this study was to explore the possibilities for the virtual prototyping of garments in regard to the sitting position, using the OptiTex 3D commercial CAD system. For this purpose 3D scans of subjects in sitting position were performed using a general-purpose ATOS II 3D optical scanning system. In addition, processing techniques of the human body mesh modeling and surface reconstruction techniques were involved to obtain a sitting 3D body model. The garments' basic pattern designs for a standing position were constructed according to the rules of the M. Müller&Sohn construction system. Their reconstruction into garments' basic pattern designs for a sitting position were performed by using the virtual measured dimensions of the scanned 3D body model in a sitting position, and virtual prototyping of the garments. Comparisons between the dimensions of the real and the 3D body models were carried out, as well as a comparison between the real sewn and virtually developed garments. The research showed that a reliable sitting 3D body model was achieved by used scanning technology, modeling and reconstruction techniques, as well as the usefulness and effectiveness of the virtual prototyping of the garments for a sitting position. In this study fully mobile individuals were involved to avoid unnecessary burdening of paraplegics in this stage of the research. The experiences gained from this study will enable us to include paraplegics within the study during the scanning and anthropometric survey with the aim of designing a general parametric 3D body model. Its body dimensions and postures would be possible for adapting from able-bodied persons with the purpose of developing individual garments for paraplegics.