Layered Double Hydroxide‐Based Functional Nanohybrids as Controlled Release Carriers of Pharmaceutically Active Ingredients

Abstract

The chemical stability, degradation and penetration ability of pharmaceutically active ingredients in topical formulations are the greatest challenges because of problems with the protection of actives for long times and with delivery. Therefore, the development of unique and efficient substrate material is vital for their protection and controlled drug release. Layered double hydroxides (LDHs) known as hydrotalcite like compounds possess positive charges due to isomorphic substitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayer region. Some of the active ingredient molecules can be intercalated into the inner region of the LDHs through ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, which are more potent for their protection and controlled-release. This account focuses on our recent research efforts and key scientific and technical challenges in the development of LDH based nanohybrids for commercial use in advanced controlled release carriers of active ingredients in topical formulations.

Fe3O4@SiO2@NiAl-LDH microspheres implication in separation, kinetic and structural properties of phenylalanine dehydrogenase

“…In recent years, these materials have shown different applications due to their special structure such as adsorbents [ [51] , [52] , [53] ], catalysts [ [54] , [55] , [56] ], as a precursor in metal oxides [ [57] , [58] , [59] , [60] ], separation [ 61 , 62 ], biology, medicine [ [63] , [64] , [65] , [66] ]. There are different methods for synthesizing LDHs such as the co-precipitation method [ [67] , [68] , [69] ], and other methods such as the sol-gel method [ [70] , [71] , [72] ], hydrothermal synthesis method [ 73 ], and urea hydrolysis method [ [74] , [75] , [76] ]. The co-precipitation method has several advantages, such as high purity and crystallinity.…”

MgAl and ZnAl-Hydrotalcites as Materials for Cosmetic and Pharmaceutical Formulations: Study of Their Cytotoxicity on Different Cell Lines

“…The layered structure, together with the ability to host anionic molecules, makes HTlc versatile materials that can find applications in many fields [ 2 ]. Among the many uses of HTlcs in pharmaceutics are those related to their being: (i) starting materials for the intercalation of active pharmaceutical ingredients (drug delivery systems) [ 3 , 4 ], (ii) active ingredients as antacids due to the high buffering capacity [ 5 ] and adsorbents nature [ 6 ], and (iii) rheological agents and fillers [ 7 , 8 , 9 ].…”

Synthesis of Organic-Inorganic Hybrid Material with a Synergistic Interface as a Release Agent for Free Acid β-Hydroxy-β-Methyl Butyrate

“…The interaction between organic with inorganic matrixes generates synergistic effects in the new structures, resulting in multifunctional materials with unique properties that could improve the physical characteristics from original constituents, even capable of overcoming the structural limitations of conventional materials [5,6]. These properties provide a variety of potential applications in multiple fields, especially for pharmaceutical and biomedical areas such as controlledrelease agents for drug delivery [7].…”

“…In this context, collagen and LDH meet prerequisites such as low toxicity to perform as drug carriers. LDH also can improve numerous relevant drug properties, such as in vivo precision and stability, improving their solubility, enhancing the drug efficiency, and protecting the "free" drugs [7].…”