Lazaroid (U-74389G) ameliorates lung injury due to lipid peroxidation and nitric oxide synthase-dependent reactive oxygen species generation caused by remote systematic ischemia-reperfusion following thoracoabdominal aortic occlusion

Perlikos, Fotis; Lagiou, Maria; Papalois, Αpostolos; Rizou, Tatiana; Kroupis, Christos; Toumpoulis, Ioannis K.

doi:10.1016/j.ijsu.2018.05.735

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…Nitric oxide (NO), a pulmonary vasodilator, is proved to perform vital functions in inhibiting platelet adhesion and maintaining the endothelial structure and function. Endothelin-1 (ET-1) is an endogenous vasoconstrictor peptide that contributes to reducing endothelial injury [31]. In this study, there is no signi cant difference between control group and TEAS group, suggesting that TEAS might have less impact on pulmonary vascular permeability.…”

Section: Discussionmentioning

confidence: 75%

Transcutaneous Electrical Acupoint Stimulation Attenuates Lung Injury Caused by Tourniquet-induced Limb Ischemia/reperfusion During Lower Extremity Surgery: A Randomized Controlled Trial

Gong

Zhao

et al. 2020

Preprint

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Background: Tourniquet-induced extremity ischemia-reperfusion injury is one of the major complications in patients with lower extremity surgery, while lung is the most vulnerable organ to insult subsequent to ischemia-reperfusion. Current scientific research data has shown that electric stimulation at special acupoints could suppress inflammasome activation and subsequently exert protective effects in the lungs. Thus, the effect of transcutaneous electrical acupuncture point stimulation (TEAS) on lung injury induced by limb ischemia/reperfusion remains to be elucidated. Methods: One hundred individuals scheduled for unilateral lower extremity surgery were randomly divided into 2 groups (n=50 each): transcutaneous electrical acupoint stimulation group (group T) and control group (group C). Patients in group T were given TEAS at FeiShu (BL13, bilateral) acupoints and ZuSanLi (ST36, non-surgical side) acupoint, while patients in group C received sham stimulation (no current) at the same acupoints for the same time as the TEAS group. Arterial blood samples were collected to assess blood gas analysis and other indicators. Results: The TEAS group showed significant improvements in blood gas analysis. Compared with group C, PaO2 and oxygenation index (OI) in group T were significantly increased at T4(4h after removing the tourniquet), while A-aDO2 and respiratory index (RI) were decreased at T4. There was an increase in the HO-1 levels in group T at T3(2h after removing the tourniquet) and T4 compared with group C. Compared with group T, SOD levels were signiﬁcantly lower at T4 in group C. At T4, the levels of ICAM-1, IL-6 and IL8 were significantly lower in group T when compared to group C. At T3 and T4, IL-10 levels were higher when compared to group C, while TNF-a levels were significantly lower.Conclusions: Transcutaneous electrical acupoint stimulation attenuates lung injury following tourniquet-induced extremity ischemia-reperfusion in patients, and HO-1 is endowed of potential mechanism of cytoprotective effects against tourniquet-induced lung injury. Trial registration: Chinese Clinical Trial Registry, ChiCTR-IOR-16008264. Registered 11 April 2016, http://www.chictr.org.cn/ ChiCTR-IOR-16008264

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Section: Discussionmentioning

confidence: 75%

Transcutaneous Electrical Acupoint Stimulation Attenuates Lung Injury Caused by Tourniquet-induced Limb Ischemia/reperfusion During Lower Extremity Surgery: A Randomized Controlled Trial

Gong

Zhao

et al. 2020

Preprint

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“…In a hind limb I/R model in rats, edaravone exert a potent protective effect against lung injury induced through its antioxidant and anti-inflammatory activities [29]. Another animal study has also shown that Lazaroid U-74389G (an anti-lipid peroxidation drug) can reduce lung ischemia-reperfusion injury once the thoracoabdominal aortic occlusion has been relieved [10], and remains an avenue of future research. Second, in a rat model, the remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process caused by clamping the abdominal aorta [30], which seems more practical in clinical setting than remote-preconditioning.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies on lung injury after aortic balloon application have mainly been conducted in animals [9,10], or have included a small sample size [11]. Due to the low incidence of pelvic and sacrum tumors, to our knowledge, no study has assessed the incidence of and factors associated with PPCs in patients undergoing pelvic and sacrum tumor resection with abdominal aortic balloon occlusion.…”

Section: Introductionmentioning

confidence: 99%

Accumulative occlusion time correlates with postoperative pulmonary complications in patients undergoing pelvic and sacrum tumor resection assisted by abdominal aortic balloon occlusion: a retrospective cohort study

Zhao

Zhang

et al. 2020

BMC Musculoskelet Disord

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Background: Postoperative pulmonary complications (PPCs) seems to be high in patients undergoing pelvic and sacrum tumor resection assisted by abdominal aortic balloon occlusion. We hypothesized that the accumulative occlusion time (AOT) of the abdominal aortic balloon may be predictive of PPCs. The objective of the study was to identify the influence of AOT on PPCs. Methods: Retrospectively analyzed perioperative factors of 584 patients who underwent pelvic and sacrum tumor resection assisted by abdominal aortic balloon occlusion in our hospital from January 1, 2016 to December 31, 2018. PPCs including suspected pulmonary infection, atelectasis, pulmonary edema, pleural effusion, respiratory failure were clinically diagnosed. Perioperative parameters among patients with and without PPCs were compared. A receiver operating characteristic (ROC) analysis was conducted to evaluate the discriminative power of AOT with regard to PPCs. A multivariate logistic-regression model was finally established to identify independent risk factors for PPCs. Results: The incidence of PPCs was 15.6% (91 patients). The median AOT in PPCs group was significantly higher than that in non-PPCs group (P < 0.001). The hospital stay was significantly prolonged in PPCs group (P < 0.001). The ROC analysis showed an AOT of 119 min as the threshold value at which the joint sensitivity (88.60%) and specificity (31.87%) was maximal. Finally, AOT ≥ 119 min (P = 0.046; odds ratio (OR) = 2.074), age (P < 0.001; OR = 1.032), ASA grade III (P = 0.015; OR = 3.264), and estimated blood loss (P = 0.022; OR = 1.235) were independent risk factors of PPCs by multivariate logistic regression analysis.

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Lazaroid (U-74389G) ameliorates lung injury due to lipid peroxidation and nitric oxide synthase-dependent reactive oxygen species generation caused by remote systematic ischemia-reperfusion following thoracoabdominal aortic occlusion

Abstract: Lazaroid U-74389G may represent an effective pharmacologic intervention in reducing lung ischemia-reperfusion injury following thoracoabdominal aortic occlusion.

Cited by 2 publications

References 29 publications

Transcutaneous Electrical Acupoint Stimulation Attenuates Lung Injury Caused by Tourniquet-induced Limb Ischemia/reperfusion During Lower Extremity Surgery: A Randomized Controlled Trial

Transcutaneous Electrical Acupoint Stimulation Attenuates Lung Injury Caused by Tourniquet-induced Limb Ischemia/reperfusion During Lower Extremity Surgery: A Randomized Controlled Trial

Accumulative occlusion time correlates with postoperative pulmonary complications in patients undergoing pelvic and sacrum tumor resection assisted by abdominal aortic balloon occlusion: a retrospective cohort study

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