LB-S&T-14 MICRO-RNA 144 ENHANCES GLUCOCORTICOID RECEPTOR BETA DURING BLADDER CANCER INVASION

Abstract

prostate disease (BPD) between subjects with and without H. pylori infection. In animal study, subcutaneous dorsal H. pylori protein extract injection in time sequential manner was used to induce chronic reaction. Systemic and prostate inflammation were evaluated by checking splenic tumor necrosis factor alpha (TNF-a), interleukin-1 beta (IL-1b), and prostatic nuclear factor-kappa B (NF-kB) respectively. Prostate was stained to confirm the location of these responses.RESULTS: Of the 24878 sampled subjects, 3688 (14.8%) had developed BPD after the index date; BPD was found in 2008 (16.1%) cases and 1680 (13.5%) controls (p<0.001). Regression analysis revealed, the OR for BPD among cases was 1.215 (95% CI ¼ 1.130-1.306, p<0.001) after adjusting for diabetes, hypertension, hyperlipidemia, coronary artery disease, urinary tract infection, and urolithiasis. In rats with protein extract injection, increased tactile hypersensitivity in scrotal base was found 15 days after injection. There were Increased TNF-a and IL-1b. Prostate inflammation was also confirmed by NF-kb and Caspase 1 staining, which was compatible with physiological changes in rats.CONCLUSIONS: There may be some link between H.pylori protein exposure and prostate inflammation. Our analysis may be only a part of the whole picture. Local prostatic inflammation may be induced by distant antigen-related systemic response.