LB918 The dark side of hydroquinone for skin lightening: 3-fold increased risk of skin cancer - a cohort study

Miles, Brittany; Wilkerson, M.

doi:10.1016/j.jid.2022.05.936

Cited by 2 publications

(1 citation statement)

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“…These discoveries demonstrate that V. corymbosum leaf extracts can have a very broad range of applications in medicine and the food industry. However, the potentially high arbutin content in the leaves, and consequently hydroquinone as well, a compound suspected of carcinogenicity [29], can raise justified concerns. Considering the beneficial properties of substances found in the leaves of highbush blueberries and the importance of substances with potentially toxic effects, in our experiment, we attempted to analyse these issues in a wide spectrum of varieties of V. corymbosum L. that are popular and widely distributed among growers around the world, not all of which have been thoroughly researched to date.…”

Section: Introductionmentioning

confidence: 99%

Content of Bioactive Compounds in Highbush Blueberry Vaccinium corymbosum L. Leaves as a Potential Raw Material for Food Technology or Pharmaceutical Industry

Czernicka,

Sowa-Borowiec,

Puchalski

et al. 2024

Foods

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This study was performed to investigate the content of selected phenolic compounds, antioxidant activity and the levels of arbutin and hydroquinone in 25 varieties of highbush blueberry (Vaccinium corymbosum) leaf samples. An analysis of the bioactive components was performed using the HPLC technique and the antioxidant activity was determined via spectrophotometric methods. The content of chlorogenic acid in the analysed leaf extracts ranged from 52.76 mg/g (Spartan variety) to 32.37 mg/g (Nelson variety) and was present in the highest concentration among all the analysed phenolic acids. Particularly large levels of isoquercetin were found in the Aurora, Ivanhoe and Toro varieties (28.40 mg/g, 26.24 mg/g and 21.57 mg/g, respectively). An exceptionally high rutin content (p < 0.05) was found in the Ivanhoe variety (27.19 mg/g) as compared to the other varieties, where it ranged from 2.06 mg/g (Earliblue and Patriot varieties) to 10.55 mg/g (Bluejay variety). The Patriot variety was determined to possess the highest antioxidative activity using the FRAP method (1086.15 μmol Trolox/g d.w.) and based on its DPPH radical scavenging activity (1124.17 μmol Trolox/g d.w.). The total phenolic content (TPC) determined via spectrophotometry ranged from 48.11 mg GAE/g d.w. (Elizabeth variety) to 177.31 GAE/g d.w. (Patriot variety). The arbutin content in the leaves of all tested varieties exceeded 2%, so it can be concluded that they constitute a stable source of arbutin. Three varieties (Bonus, Chanticleer and Herbert) can be considered a potential alternative to bearberry and lingonberry leaves. The hydroquinone content in the analysed extracts was determined to be at a lower level. V. corymbosum leaves can be considered an interesting herbal material for use in traditional herbal medicinal products but not directly for food products and dietary supplements.

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Section: Introductionmentioning

confidence: 99%