LBA1 Mechanism of action and an actionable inflammatory axis for air pollution induced non-small cell lung cancer: Towards molecular cancer prevention

Swanton, C.; Hill, William; Lim, Emilia L.; Lee, C.; Weeden, Clare E.; Augustine, M.; Chen, K.; Kuan, F-C.; Marongiu, F.; Rodrigues, Felipe Silva; Cha, Hongui; Jacks, Tyler; Lüchtenborg, Margreet; Malanchi, Ilaria; Downward, Julian; Carlsten, Christopher; Hackshaw, A; Litchfield, K.R.; DeGregori, James; Jamal‐Hanjani, Mariam

doi:10.1016/j.annonc.2022.08.046

Cited by 33 publications

(25 citation statements)

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“…As mutated cells near the crypt surface normally undergo anoikis and are shed into the lumen, this evidence supports a top‐down model of CRC initiation that can arise if the ISC pool is depleted by dietary or inflammatory means (Ngo et al, 2022). The idea that environmental factors and inflammation prime cells to initiate tumorigenesis, independent of carcinogen‐induced mutagenesis, was recently supported by Swanton et al (2022). A high‐fat diet (HFD) is known to increase inflammation and associated CRC risk, as opposed to exercise and dietary fiber that dampen inflammation and CRC risk (Byrd et al, 2020).…”

Section: Balancing the Scales Of Colorectal Cancer: Can Healthy Lifes...mentioning

confidence: 98%

Balancing the scales: Do healthy lifestyle choices offset the colorectal cancer risk of unhealthy choices?

Williams

Parry

2022

eFood

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Section: Balancing the Scales Of Colorectal Cancer: Can Healthy Lifes...mentioning

confidence: 98%

Balancing the scales: Do healthy lifestyle choices offset the colorectal cancer risk of unhealthy choices?

Williams

Parry

2022

eFood

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“…More recent data has identified a potential mechanism for the recognised link between air pollution and lung cancer. Swanton et al (2022) found that exposure to 2.5 µm particulate matter led to an influx of macrophages and inflammatory mediators including IL-1β which induces a progenitor-like state in the lung epithelium harbouring mutant EGFR, promoting tumor formation. Together, these findings provide compelling evidence of a role for IL-1β in tumorigenesis, and highlight the ongoing work needed to identify valid biomarkers in this patient population in order harness the therapeutic potential of IL-1β blockade for patients with breast cancer and other solid tumor malignancies.…”

Section: Pre-clinical Models Supporting Il1β Inhibition For Tnbcmentioning

confidence: 99%

Exploring immune interactions in triple negative breast cancer: IL-1β inhibition and its therapeutic potential

et al. 2023

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Triple negative breast cancer (TNBC) has poor prognosis when compared to other breast cancer subtypes. Despite pre-clinical data supporting an immune targeted approach for TNBCs, immunotherapy has failed to demonstrate the impressive responses seen in other solid tumor malignancies. Additional strategies to modify the tumor immune microenvironment and potentiate response to immunotherapy are needed. In this review, we summarise phase III data supporting the use of immunotherapy for TNBC. We discuss the role of IL-1β in tumorigenesis and summarize pre-clinical data supporting IL-1β inhibition as a potential therapeutic strategy in TNBC. Finally, we present current trials evaluating IL-1β in breast cancer and other solid tumor malignancies and discuss future studies that may provide a strong scientific rationale for the combination of IL-1β and immunotherapy in the neoadjuvant and metastatic setting for people with TNBC.

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“…For a 50-year old person, lung cells with potentially cancer mutations are at a frequency of around one in every 600,000 cells, due to damage to our cell’s DNA as we age. The new postulate is that the released interleukin-1β had woken up damaged cells that appear to be healthy but are normally inactive to give rise to lung cancer [ 78 ].…”

Section: Waking Up Old and Damaged Cellsmentioning

confidence: 99%

Hematopoietic and Chronic Myeloid Leukemia Stem Cells: Multi-Stability versus Lineage Restriction

Brown

2022

IJMS

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There is compelling evidence to support the view that the cell-of-origin for chronic myeloid leukemia is a hematopoietic stem cell. Unlike normal hematopoietic stem cells, the progeny of the leukemia stem cells are predominantly neutrophils during the disease chronic phase and there is a mild anemia. The hallmark oncogene for chronic myeloid leukemia is the BCR-ABLp210 fusion gene. Various studies have excluded a role for BCR-ABLp210 expression in maintaining the population of leukemia stem cells. Studies of BCR-ABLp210 expression in embryonal stem cells that were differentiated into hematopoietic stem cells and of the expression in transgenic mice have revealed that BCR-ABLp210 is able to veer hematopoietic stem and progenitor cells towards a myeloid fate. For the transgenic mice, global changes to the epigenetic landscape were observed. In chronic myeloid leukemia, the ability of the leukemia stem cells to choose from the many fates that are available to normal hematopoietic stem cells appears to be deregulated by BCR-ABLp210 and changes to the epigenome are also important. Even so, we still do not have a precise picture as to why neutrophils are abundantly produced in chronic myeloid leukemia.

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LBA1 Mechanism of action and an actionable inflammatory axis for air pollution induced non-small cell lung cancer: Towards molecular cancer prevention

Cited by 33 publications

References 0 publications

Balancing the scales: Do healthy lifestyle choices offset the colorectal cancer risk of unhealthy choices?

Balancing the scales: Do healthy lifestyle choices offset the colorectal cancer risk of unhealthy choices?

Exploring immune interactions in triple negative breast cancer: IL-1β inhibition and its therapeutic potential

Hematopoietic and Chronic Myeloid Leukemia Stem Cells: Multi-Stability versus Lineage Restriction

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