LC-MS analysis of<i>Myrica rubra</i>extract and its hypotensive effects<i>via</i>the inhibition of GLUT 1 and activation of the NO/Akt/eNOS signaling pathway

Li, Jing; Wang, Huiling; Li, Jian; Liu, Yonggang; Ding, Hong

doi:10.1039/c9ra05895h

Cited by 5 publications

(10 citation statements)

References 65 publications

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“…The pathways of PI3K‐Akt, 48,49 Wnt, 50 ATM, 51 dopaminergic synapse, 18,52 ECM–receptor interaction, 53 glutathione metabolism, 54 renin secretion 55,56 and adherens junction 57 were related to differential metabolites of the PG group. The pathways of AKT, 58 linoleic acid metabolism, 59 FoxO, 60 ceramide, 61,62 cell adhesion molecules 21 and adipocytokine 63 were related to differential metabolites of the AMG group. KEGG enrichment analysis was also performed to show the pathways in which the differential metabolites were involved (Figure 5).…”

Section: Resultsmentioning

confidence: 97%

Identification of metabolites in plasma related to different biological activities of Panax ginseng and American ginseng

Liu

Dong

et al. 2021

Rapid Comm Mass Spectrometry

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Rationale Panax ginseng (PG) and American ginseng (AMG) are both medicinal plants of the Panax genus in the Acanthopanax family. Although PG and AMG have similar components of ginsenosides, there are many differences of their bioactivities. In this study, the biochemical mechanisms of different bioactivities of PG and AMG were explored by researching the differential metabolites in plasma after administration of each of PG and AMG. Methods In order to explore the material basis of differential bioactivities, two groups of mice were administrated orally with PG and AMG, and the method of metabolomics was used to identify the differential metabolites in plasma. Then network pharmacology was used based on the differential metabolites. Afterward, the metabolite–target–pathway network of PG and AMG was constructed; thus the pathways related to different bioactivities were analyzed. Results Through principal component analysis and orthogonal projections to latent structures discriminant analysis, there were 10 differential metabolites identified in the PG group and 8 differential metabolites identified in the AMG group. Based on network pharmacology, the differential metabolites were classified and related to differential bioactivities of PG and AMG. In the PG group, there were 6 metabolites related to aphrodisiac effect and exciting the nervous system, and 5 metabolites associated with raised blood pressure. In the AMG group, 5 metabolites were classified as having the effect of inhibiting the nervous system, and 6 metabolites were related to antihypertensive effect. Conclusions This study explored the material basis of the differential biological activities between PG and AMG, which is significant for the research of PG and AMG use and to promote human health.

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Section: Resultsmentioning

confidence: 97%

Identification of metabolites in plasma related to different biological activities of Panax ginseng and American ginseng

Liu

Dong

et al. 2021

Rapid Comm Mass Spectrometry

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“…Bayberry extracts have been shown to have multiple bioactivities such as antioxidant, hepatoprotective, antidiarrheal, and hypolipidemic activities, − which were mainly contributed to the phenolic compounds in fruit pulp. Anthocyanins and flavonoid glycosides have been reported to be the main phenolic compounds in bayberry pulp. − However, a comprehensive knowledge of the phenolic compounds and their changes during the developmental stages of bayberry fruits, especially for the white-colored cultivar, have yet to be disclosed.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Profiling of Phenolic Compounds in White and Red Chinese Bayberries (Morella rubra Sieb. et Zucc.) and Their Developmental Variations Using Tandem Mass Spectral Molecular Networking

Lyu

Wen

Liu

et al. 2021

J. Agric. Food Chem.

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Chemical structural characterization of phenolic compounds from the red ("Biqi") and white ("Shuijing") bayberries was carried out in the present study. With the aid of Global Natural Products Social Molecular Networking (GNPS), 18 flavonoid glycosides and 13 proanthocyanidins (PACs) in bayberry extracts were tentatively identified. Three cyanidin-3-glucoside derivatives (cyanidin-acetylapiosyl-glucoside, catechin-cyanidin-3-glucoside, and gallocatechin-cyanidin-3-glucoside), two quercetin derivatives (quercetin-3-arabinoside and quercetin-3-glucuronide), patuletin-7-glucoside, and individual PACs consisting of (epi)catechin or (epi)gallocatechin units were reported for the first time in bayberry fruits. In addition, "Biqi" exhibited a considerable increase of flavonoid glycoside content together with a dramatic decrease in the content of PACs in mature fruits, while "Shuijing" showed a decrease in levels of PACs but failed to accumulate flavonoid glycosides during fruit development.

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“…NOS is formed by a group of three enzymes ( e NOS, n NOS, and i NOS), which are responsible for the generation of nitric oxide (NO) from the amino acid L -arginine [ 77 , 78 ]. NO is a free radical gas and is associated with several biological functions, playing key roles in the regulation of blood flow, blood pressure, and oxygen delivery [ 79 – 81 ].…”

Section: Introductionmentioning

confidence: 99%

“…e NOS acts directly on the NO formation rate and acts as a limiting enzyme for this process, based on its expression levels and biological activity [ 78 , 87 ]. e NOS activity also influences the maintenance of vascular and endothelial homeostasis [ 88 – 90 ], in addition to the structure and function of the vascular endothelium [ 90 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of New Targets and the Virtual Screening of Lignans against Alzheimer’s Disease

Maia

Rodrigues

Sousa

et al. 2020

Oxidative Medicine and Cellular Longevity

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Alzheimer’s disease (AD) is characterized by the progressive disturbance in cognition and affects approximately 36 million people, worldwide. However, the drugs used to treat this disease are only moderately effective and do not alter the course of the neurodegenerative process. This is because the pathogenesis of AD is mainly associated with oxidative stress, and current drugs only target two enzymes involved in neurotransmission. Therefore, the present study sought to identify potential multitarget compounds for enzymes that are directly or indirectly involved in the oxidative pathway, with minimal side effects, for AD treatment. A set of 159 lignans were submitted to studies of QSAR and molecular docking. A combined analysis was performed, based on ligand and structure, followed by the prediction of absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. The results showed that the combined analysis was able to select 139 potentially active and multitarget lignans targeting two or more enzymes, among them are c-Jun N-terminal kinase 3 (JNK-3), protein tyrosine phosphatase 1B (PTP1B), nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1), NADPH quinone oxidoreductase 1 (NQO1), phosphodiesterase 5 (PDE5), nuclear factor erythroid 2-related factor 2 (Nrf2), cycloxygenase 2 (COX-2), and inducible nitric oxide synthase (iNOS). The authors conclude that compounds (06) austrobailignan 6, (11) anolignan c, (19) 7-epi-virolin, (64) 6-[(2R,3R,4R,5R)-3,4-dimethyl-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]-4-methoxy-1,3-benzodioxole, (116) ococymosin, and (135) mappiodoinin b have probabilities that confer neuroprotection and antioxidant activity and represent potential alternative AD treatment drugs or prototypes for the development of new drugs with anti-AD properties.

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LC-MS analysis ofMyrica rubraextract and its hypotensive effectsviathe inhibition of GLUT 1 and activation of the NO/Akt/eNOS signaling pathway

Abstract: In the area of medicine food homology, Myrica rubra ((Lour.) Siebold & Zucc.) has been used in medicine as an astringent and anti-diarrheal.

Cited by 5 publications

References 65 publications

Identification of metabolites in plasma related to different biological activities of Panax ginseng and American ginseng

Identification of metabolites in plasma related to different biological activities of Panax ginseng and American ginseng

Comprehensive Profiling of Phenolic Compounds in White and Red Chinese Bayberries (Morella rubra Sieb. et Zucc.) and Their Developmental Variations Using Tandem Mass Spectral Molecular Networking

Identification of New Targets and the Virtual Screening of Lignans against Alzheimer’s Disease

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