LC/MS applications in drug development

Abstract

At many times during this project I found myself asking the question,"Why am I doing this?" In my attempt to answer, I would always seem to recount my positive experiences with the analytical sciences. Thus, I feel compelled to give thanks to those who were integral to my education in the analytical sciences and inspirations to my professional development. First, I thank the University of Maryland for encouraging me to pursue an education in the sciences. Second, I thank the graduate program at the University of Florida for providing me an opportunity to focus in the analytical sciences and teaching me how to formulate question and thought. Third, I thank Bristol-Myers Squibb for balancing my hunger for the application of analytical sciences with the need to experience collaboration, interaction, and growth. To each of the above mentioned institutions, I am grateful for the support and continued source of inspiration. To all the people at the above mentioned institutions, I will hold dear the friendships, relationships, and memories that are the result of success and failure. And finally, I wish to thank my loving wife and family for their continual encouragement and support for everything I do. For this, I am truly blessed. xii ACKNOWLEDGMENTS CHAPTER 1 1

Automated nanospray using chip-based emitters for the quantitative analysis of pharmaceutical compounds

“…Liquid chromatography/tandem mass spectrometry (LC/MS/MS) methods, with atmosphericpressure chemical ionization (APCI) or electrospray ionization (ESI) with pneumatic assistance, the latter commercially available as IonSpray, are frequently used for quantitative determination of drug candidates in biological matrices [1]. The main attractions of LC/MS/MS are the attributes of selectivity, sensitivity, and reproducibility [2].…”

In vivo pharmacological evaluation of a lactose-conjugated luteinizing hormone releasing hormone analogue

“…LC/MS is an automated technique with broad applications in quantification of pharmaceutical compounds and their metabolites in biological matrices. The selectivity, sensitivity and cost effectiveness of MS based methods make them a preferred analytical technique in pharmaceutical industry (Lee, 2003). The developed method in this study was capable of detecting the compound over a range of 0.01 to 20 µg/ml with a detection limit of 0.01 µg/ml.…”

Impurity: Pharma Market and Importance

“…Key players in the global API market include Teva Pharmaceutical Industries Ltd., and Zhejiang NHU Co., Ltd, Zhejiang Medicine Co. North China Pharmaceutical Group Corp. (NCPC) and Northeast Pharmaceutical Group Co, Dr. Reddy's Laboratories Ltd., Aurobindo Pharma, Sandoz (Novartis AG), Zhejiang Huahai Pharmaceutical Co.,Ltd, Ltd and Zhejiang Hisun Pharmaceutical Co., Ltd [11][12][13][14][15].…”