LC-MS–MS characterisation of curry leaf flavonols and antioxidant activity

Singh, Ajay P.; Wilson, Ted; Luthria, Devanand L.; Freeman, Michele; Scott, Rachel M.; Bilenker, Dan; Shah, Sneha; Somasundaram, Siva G; Vorsa, Nicholi

doi:10.1016/j.foodchem.2010.12.091

Cited by 68 publications

(54 citation statements)

References 15 publications

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“…In our previous work, we have observed that leaves of Indian curry leaf plants are rich in polyphenols, flavonoids, such as quercetin, and quercetin-3-glucoside [16]. Other reported flavonoids present in aqueous methanol extract of leaves of this plant are myricetin-3-galactoside, quercetin-O-pentohexoside, quercetin-3-diglucoside, quercetin-3-Orutinoside, quercetin-3-acetylhexoside, kaempferol-O-glucoside, and kaempferol-aglucoside [24]. We have also isolated and identified four carbazole alkaloids by column chromatography of the gummy mass obtained from AMEL.…”

Section: Instrumentationmentioning

confidence: 94%

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Green-nanochemistry for safe environment: bio-friendly synthesis of fluorescent monometallic (Ag and Au) and bimetallic (Ag/Au alloy) nanoparticles having pesticide sensing activity

et al. 2016

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Aqueous methanol (water:methanol 20:80) extract of leaves (AMEL) of Indian curry leaf plant was found to be highly efficient in the rapid and controlled synthesis of stable and fluorescent monometallic (Ag and Au) and also bimetallic (Ag/Au alloy) nanoparticles with wide spectrum of task specific morphologies under sonochemical condition. The nanoparticles synthesized by the present economically viable and environment-friendly protocol showed characteristic fluorescence activity. This was exploited in the fluorometric sensing of the dithiocarbamate pesticide, Mancozeb in aqueous medium. The surface chemistry of these nanoparticles was extensively studied to understand their sensing activity. The naturally occurring flurophoric/chromophoric compounds (carbazole alkaloids and polyhydroxy flavonoid) present in AMEL instilled (in situ) strong and characteristic fluorescent behavior to the synthesized nanoparticles which opened up their utility as the fluorometric sensors and detectors for pesticides in aqueous medium.

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Section: Instrumentationmentioning

confidence: 94%

“…; Family: Rutaceae) and it is non-toxic and less expensive, therefore, easily available. Leaves of this traditionally used medicinal plant are extensively used in Indian cuisine, and as a whole, this plant is the rich sources of wide spectrum of multifunctional and biologically active natural products [23,24].…”

Section: Introductionmentioning

confidence: 99%

Green-nanochemistry for safe environment: bio-friendly synthesis of fluorescent monometallic (Ag and Au) and bimetallic (Ag/Au alloy) nanoparticles having pesticide sensing activity

et al. 2016

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“…Another study has reported that the carbazole alkaloid mahanimbine has antioxidative activity by acetylcholinesterase inhibition [19]. Major curry leaf flavonols are myricetin-3-galactoside, quercetin-O-pentohexoside, quercetin-3-diglucoside, quercetin-3-O-rutinoside, quercetin-3-glucoside, quercetin-3-acetylhexoside, quercetin-O-xylo-pentoside, kaempferol-O-glucoside, and kaempferol-aglucoside, and it has been demonstrated that curry leaf phenolics prevent cupric-ion-induced oxidation of low-density lipoproteins [20]. Thus, the M. koenigii extract influences some immunological parameters along with its bactericidal properties in the body and as an anti-inflammatory agent.…”

Section: Discussionmentioning

confidence: 99%

Augmented primary humoral immune response and decreased cell-mediated immunity by Murraya koenigii in rats

Kaur

Bhatia

Bhati

et al. 2013

Journal of Basic and Clinical Physiology and Pharmacology

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“…This plant is widely cultivated for its leaves which possess characteristic flavor and aroma and are used as a condiment and flavoring agent in ethnic foods [1, 2]. Traditionally, the leaves of this plant are used to treat a wide range of diseases and disorders such as pain, inflammation, itching, cancer, diabetes, and blood disorders [1, 3].…”

Section: Introductionmentioning

confidence: 99%

The Methanolic Extract fromMurraya koenigiiL. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K⁺Channel as Antinociceptive Mechanism

Ani

Chakraborty

Moniruzzaman

2016

Advances in Pharmacological Sciences

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Murraya koenigii L. is a perennial shrub, belonging to the family Rutaceae. Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation. Although researchers have revealed the antinociceptive effects of this plant's leaves during past few years, the mechanisms underlying these effects are still unknown. Therefore, the present study evaluated some antinociceptive mechanisms of the methanolic extract of M. koenigii (MEMK) leaves along with its antinociceptive potential using several animal models. The antinociceptive effects of MEMK were evaluated using formalin-induced licking and acetic acid-induced writhing tests at the doses of 50, 100, and 200 mg/kg. In addition, we also justified the possible participations of glutamatergic system and ATP-sensitive potassium channels in the observed activities. Our results demonstrated that MEMK significantly (p < 0.01) inhibited the pain thresholds induced by formalin and acetic acid in a dose-dependent manner. MEMK also significantly (p < 0.01) suppressed glutamate-induced pain. Moreover, pretreatment with glibenclamide (an ATP-sensitive potassium channel blocker) at 10 mg/kg significantly (p < 0.05) reversed the MEMK-mediated antinociception. These revealed that MEMK might have the potential to interact with glutamatergic system and the ATP-sensitive potassium channels to exhibit its antinociceptive activities. Therefore, our results strongly support the antinociceptive effects of M. koenigii leaves and provide scientific basis of their analgesic uses in the traditional medicine.

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LC-MS–MS characterisation of curry leaf flavonols and antioxidant activity

Cited by 68 publications

References 15 publications

Green-nanochemistry for safe environment: bio-friendly synthesis of fluorescent monometallic (Ag and Au) and bimetallic (Ag/Au alloy) nanoparticles having pesticide sensing activity

Green-nanochemistry for safe environment: bio-friendly synthesis of fluorescent monometallic (Ag and Au) and bimetallic (Ag/Au alloy) nanoparticles having pesticide sensing activity

Augmented primary humoral immune response and decreased cell-mediated immunity by Murraya koenigii in rats

The Methanolic Extract fromMurraya koenigiiL. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K⁺Channel as Antinociceptive Mechanism

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LC-MS–MS characterisation of curry leaf flavonols and antioxidant activity

Cited by 68 publications

References 15 publications

Green-nanochemistry for safe environment: bio-friendly synthesis of fluorescent monometallic (Ag and Au) and bimetallic (Ag/Au alloy) nanoparticles having pesticide sensing activity

Green-nanochemistry for safe environment: bio-friendly synthesis of fluorescent monometallic (Ag and Au) and bimetallic (Ag/Au alloy) nanoparticles having pesticide sensing activity

Augmented primary humoral immune response and decreased cell-mediated immunity by Murraya koenigii in rats

The Methanolic Extract fromMurraya koenigiiL. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+Channel as Antinociceptive Mechanism

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The Methanolic Extract fromMurraya koenigiiL. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K⁺Channel as Antinociceptive Mechanism