LC-MS/MS phenolic composition of peach (Prunus persica (L.) Batsch) extracts and an evaluation of their antidiabetic, antioxidant, and antibacterial activities

Gedük, Aysun Şener; Atsız, Selma

doi:10.1016/j.sajb.2022.02.026

Cited by 10 publications

(7 citation statements)

References 44 publications

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“…Overall, in agreement with our results, the polar solvent extracts from Primula species showed greater radical scavenging abilities than nonpolar solvent extracts. Recent studies have shown that alcohol and hydroalcoholic extracts have a great potential to extract more phenolic compounds from plant samples [ 54 , 55 , 56 ]. In addition, several authors reported the free radical scavenging abilities of some Primula species [ 57 , 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications

et al. 2022

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The biological activity of the aerial part and rhizomes of Primula auriculata were assessed for the first time. The biological activities (antioxidant properties, enzyme inhibition, and AGE inhibition) as well as the phenolic and flavonoid contents of the ethyl acetate, ethanol, hydro-ethanol and water extracts of P. auriculata aerial parts and rhizomes were determined. Cell viability assays and gelatin zymography were also performed for MMP-2/-9 to determine the molecular mechanisms of action. The gene expression for MMPs was described with RT-PCR. The levels of various proteins, including phospho-Nf-κB, BCL-2, BAX, p-53, and cyclin D1 as well as RAGE were measured using Western blot analysis. The hydro-ethanol extract of the aerial part possessed the highest phenolic (56.81 mg GAE/g) and flavonoid (63.92 mg RE/g) contents. In-depth profiling of the specialized metabolites by ultra-high-performance liquid chromatography—high-resolution mass spectrometry (UHPLC-HRMS) allowed for the identification and annotation of 65 compounds, including phenolic acids and glycosides, flavones, flavonols, chalcones, dihydrochalcones, and saponins. The hydro-ethanol extract of the aerial parts (132.65, 180.87, 172.46, and 108.37 mg TE/g, for the DPPH, ABTS, CUPRAC, and FRAP assays, respectively) and the ethanol extract of the rhizomes (415.06, 638.30, 477.77, and 301.02 mg TE/g, for the DPPH, ABTS, CUPRAC, and FRAP assays, respectively) exhibited the highest free radical scavenging and reducing activities. The ethanol and hydro-ethanol extracts of both the P. auriculata aerial part and rhizomes exhibited higher inhibitory activity against acetylcholinesterase, while the hydro-ethanol extracts (1.16 mmol ACAE/g, for both the aerial part and rhizomes extracts) were more active in the inhibition of α-glucosidase. After the treatment of an HT-29 colorectal cancer cell line with the extracts, the apoptosis mechanism was initiated, the integrity of the ECM was remodeled, and cell proliferation was also taken under control. In this way, Primula extracts were shown to be potential drug sources in the treatment of colorectal cancer. They were also detected as natural MMP inhibitors. The findings presented in the present study appraise the bioactivity of P. auriculata, an understudied species. Additional assessment is required to evaluate the cytotoxicity of P. auriculata as well as its activity in ex vivo systems.

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Section: Resultsmentioning

confidence: 99%

An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications

et al. 2022

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“…According to Vizzotto et al's [112] research, red-fleshed peaches had a higher phenolic content than light-fleshed peaches. The ethanolic pomace extract was found to be richer in phenolics than the methanolic extract [113], whereas Loizzo et al [110] concluded that peach pomace is characterized by a higher phenolic concentration than peach peels and seeds. However, Liu et al [109] and Saidani et al [12] reported that the phenolic content of peach peels is substantially higher than that of peach pomace.…”

Section: Peach Pomace Identificationmentioning

confidence: 96%

“…According to Zuo et al [116], chlorogenic acid has a variety of health advantages, including an antidiabetic effect, DNA protection effect, neuroprotective effect, and inhibitory activity against hepatitis B virus. Geduk and Atsız [113] noted that the ethanolic pomace extract had a substantially higher chlorogenic acid content than the methanolic extract. Neochlorogenic acid is another hydroxycinnamic acid present in peach pomace, with a concentration that is noticeably lower than that of chlorogenic acid [12,54,109,113].…”

Section: Peach Pomace Identificationmentioning

confidence: 99%

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Valorization of Peach By-Products: Utilizing Them as Valuable Resources in a Circular Economy Model

Solomakou,

Drosaki,

Kaderides

et al. 2024

Sustainability

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Peach processing generates significant amounts of by-products including peels, pomace, and seeds that are often discarded as waste, despite their rich content of bioactive components. Various methods, such as solvent extraction, ultrasound-assisted extraction, and alkaline and acid hydrolysis, have been employed to recover valuable components from peach by-products. These compounds have shown potential applications in the food, pharmaceutical, and cosmetic industries due to their antioxidant, antimicrobial, and anti-inflammatory properties. Furthermore, these wastes can also be used to produce functional ingredients, natural colorants, and dietary supplements. Alternative uses include animal feed, composting materials, and biofuels. This comprehensive review provides an overview of the valorization of peach by-products, focusing on the isolation of valuable compounds, the techniques used, and the potential applications of the obtained compounds.

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“…With widely targeted metabolomics analysis, thousands of metabolites can be quickly detected and accurately quantified to assess the metabolome underlying the phenotype of organisms and investigate metabolite variability among different organs, varieties, and species ( Scalbert et al., 2011 ). This approach has been widely used in fruit metabolite analysis, including peach ( Gedük and Atsız, 2022 ), kiwifruit ( Li et al., 2023 ), cherry ( Yang et al., 2021 ), and blueberry ( Zheng et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Widely targeted metabolome profiling of different plateau raspberries and berry parts provides innovative insight into their antioxidant activities

Ren

Wang

et al. 2023

Front. Plant Sci.

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Raspberries are highly nutritious and have powerful antioxidant properties, making them functional berries with positive effects on physiological functioning. However, there is limited information available on the diversity and variability of metabolites in raspberry and its parts, especially in plateau raspberries. To address this, commercial raspberries and their pulp and seeds from two plateaus in China were subjected to LC-MS/MS-based metabolomics analysis and evaluated for antioxidant activity using four assays. A metabolite-metabolite correlation network was established based on antioxidant activity and correlation analysis. The results showed that 1661 metabolites were identified and classified into 12 categories, with significant variations in composition between the whole berry and its parts from different plateaus. Flavonoids, amino acids and their derivatives, and phenolic acids were found to be up-regulated in Qinghai’s raspberry compared to Yunnan’s raspberry. The main differently regulated pathways were related to flavonoid, amino acid, and anthocyanin biosynthesis. The antioxidant activity of Qinghai’s raspberry was stronger than Yunnan’s raspberry, and the order of antioxidant capacity was seed > pulp > berry. The highest FRAP (420.31 µM TE/g DW) values was found in the seed of Qinghai’s raspberry. Overall, these findings suggest that the environment in which the berries grow can affect their chemical composition, and comprehensive exploitation and cultivation of whole raspberry and its parts from different plateaus can lead to new opportunities for phytochemical compositions and antioxidant activity.

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LC-MS/MS phenolic composition of peach (Prunus persica (L.) Batsch) extracts and an evaluation of their antidiabetic, antioxidant, and antibacterial activities

Cited by 10 publications

References 44 publications

An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications

An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications

Valorization of Peach By-Products: Utilizing Them as Valuable Resources in a Circular Economy Model

Widely targeted metabolome profiling of different plateau raspberries and berry parts provides innovative insight into their antioxidant activities

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