LC‐study of lonazolac, naproxen and related non‐steroidal anti‐inflammatory drugs in a classical and a narrow‐bore setup applying UV and fluorescence detection

A method is described for the simultaneous analysis of 14 non-steroidal anti-inflammatory drugs (NSAIDS) in human serum using negative electrospray ionization-tandem mass spectrometry (ESI-MS/MS). After addition of internal standard and protein precipitation using acetonitrile, samples were transferred to autosampler vials for direct analysis without chromatography. Injection of an air bubble with the sample and a multiple reaction monitoring (MRM) method using argon collision-induced dissociation (CID) of analyte (M-H)- ions permitted integration of the product ion peak areas to produce reproducible quantitative data over the range of concentrations expected in serum during routine use of these drugs. The method permitted the analysis of 30 samples per hour. Two hundred fifty consecutive analyses did not adversely affect instrument sensitivity.

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Spectrophotometric Determination of Naproxen in Pure and Pharmaceutical Preparations

Khan¹,

Aman²,

Ashraf³

et al. 1999

Analytical Letters

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LC‐study of lonazolac, naproxen and related non‐steroidal anti‐inflammatory drugs in a classical and a narrow‐bore setup applying UV and fluorescence detection

Cited by 3 publications

References 2 publications

Comparison of morphine and hydromorphone analysis on reversed phase columns with different diameters

Comparison of morphine and hydromorphone analysis on reversed phase columns with different diameters

Simultaneous analysis of 14 non-steroidal anti-inflammatory drugs in human serum by electrospray ionization-tandem mass spectrometry without chromatography

Spectrophotometric Determination of Naproxen in Pure and Pharmaceutical Preparations

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