We mainly report an efficient approach to optimize the design of beaconless spatial laser acquisition. In order to analyze the influence of vibration environment on the beaconless spatial acquisition, a demonstration of an efficient method will be presented to simulate the level of satellite platform vibration. An important power spectral density (PSD) model of satellite platform vibration used by the European Space Agency is introduced. Then through LABVIEW, a simulated vibration waveform is generated, and the simulated PSD has a basic consistency with the in-orbit measurement spectral line, referring to the design of the filter, generating the Gaussian white noise sequence, filtering the pseudorandom signal and the whole processing procedure of parameter matching. The variation interval of the vibration amplitude is from −100 to 40 μrad. Then, the model of beaconless acquisition is proposed, which uses the spiral scan pattern, laser with a divergence angle of 80 μrad scan in an uncertainty cone (UC), and also the scan coupled with the simulated vibration is given. Through the beaconless acquisition program, the vibration is suppressed between −10.7 and 5.9 μrad; when the overlap factor is selected as 10%, it does not produce any leakage scanning area. It can be used for a wide variety of platforms. This new method will be good for analysis and test of beaconless spatial acquisition algorithm. Finally, the description of acquisition duration, which mainly includes the fast steering mirror spiral scan and the mechanical rotary table step scan, is introduced. And the corresponding optimal selection method of sub-region is proposed; the design of 1.6-mrad scanning pattern with 7 × 7 sub-regions in the 8-mrad acquisition UC is given. Through the actual measurement, the acquisition time is 18.21 s, the tracking error is better than 0.4 μrad.