LDH and Fibrinogen-Fibrin Degradation Products in Pulmonary Embolism

Light, Richard W.; Bell, William R.

doi:10.1001/archinte.1974.00320150046004

Cited by 11 publications

(1 citation statement)

References 18 publications

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“…464 Since heparin is promptly effective in inhibiting the con-sumption of fibrinogen and production of FDPs, it is postulated that the previous reports of enhanced fibrinolysis associated with pulmonary embolism may, in fact, have represented DIC as a complica tion of the embolic event. [465][466][467][468][469][470] The degree of vas cular occlusion is not directly related to the degree of elevation of FDPs. 467 In the National Heart and Lung Institute urokinase pulmonary embolism trial, a higher mortality is noted to be associated with pretherapy, decreased levels of fibrinogen and platelets, and prolongation of the PT.…”

Section: Venous Thromboembolic Diseasementioning

confidence: 99%

Clinical Aspects of Disseminated Intravascular Coagulation: A Clinician's Point of View

Baker¹

1989

Semin Thromb Hemost

151

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DIC is a disorder of coagulation that is demonstrated to occur in many settings. In view of the fulminant nature of the disorder once it is fully activated, the potential for considerable morbidity and mortality, and the difficulty in treating this syndrome, the necessity for a thorough understanding of the disorder is clear. A high index of suspicion is absolutely essential; however, this requires a thorough knowledge of the medical and surgical disorders in which DIC is likely to occur. The presenting manifestations of DIC, the time course of development of the fulminant syndrome, and the specific complications of the disorder may be intrinsically related to the specific clinical characteristics of the underlying disease. Clinical evaluation of the patient must be comprehensive and consider not only the laboratory and clinical manifestations of DIC but the triggering illness. Without the ability to treat the underlying primary illness, controlling or abating the DIC may be difficult or impossible. This comprehensive review of the disease entities in which DIC is likely to occur and the associated clinical manifestations will, it is hoped, guide a more precise definition of the overall clinical picture that confronts the clinician when evaluating a patient with possible DIC.

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