LDH isoenzyme pattern in a meningioma with pulmonary metastases

Allen, Ingrid V.; McClure, James H.; McCormick, D.; Gleadhill, Colin A.

doi:10.1002/path.1711230309

Cited by 20 publications

(7 citation statements)

References 5 publications

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“…Although at least three published reports detailing FNABs of nonangioblastic meningioma metastatic to the lung exist [15][16][17] and extensive secondary pleural spread is known, 4 we could not find any cytologic documentation of meningioma in pleural effusions. Examination of pleural fluid from a patient with meningioma metastatic to the pleura and lung has been reported but no tumor cells were found in it.…”

Section: Discussionmentioning

confidence: 63%

“…3 Death from respiratory failure due to extensive pulmonary/pleural metastases, as in our case, is extraordinary. [4][5][6] Primary intracranial meningiomas have been sampled cytologically by fine-needle aspiration biopsy (FNAB), 7,8 intraoperative tumor imprints, 9 crush preparations, 10,11 and Cavitron ultrasonic surgical aspiration. 12 FNABs of extracranial 13,14 and metastatic meningiomas [15][16][17] also have been documented.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic meningioma detected in pleural fluid

1998

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Meningiomas with both malignant cytologic features and clinical behavior are rare. A 39‐yr‐old man with recurrent meningioma developed a pleural effusion which, on cytologic examination, contained metastatic meningioma. The diagnosis was subsequently confirmed histologically and ultrastructurally. In conclusion, metastatic meningiomas can retain meningotheliomatous cytologic features which may allow a diagnosis to be made of clinically unanticipated tumor spread. Diagn. Cytopathol. 1998;18:453–457. © 1998 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Metastatic meningioma detected in pleural fluid

1998

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“…Most spread is hematogenous, especially in tumors that invade the dural sinuses. Blood-borne passage of tumor cells through venous channels is the most likely mechanism for distal spread, since metastases are associated with prior surgery or invasion of the venous system [15, 16]. A second route of dissemination is through the cerebrospinal fluid, leading to tumor within the neuroaxis [17].…”

Section: Discussionmentioning

confidence: 99%

Multiple Pulmonary Metastases following Total Removal of a Bilateral Parasagittal Meningioma with Complete Occlusion of the Superior Sagittal Sinus: Report of a Case

Tanaka

Nakamura

Watanabe

et al. 2012

Case Reports in Neurological Medicine

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Pulmonary metastases of benign meningiomas are extremely rare. The case of a 34-year-old man with bilateral parasagittal meningioma who developed pulmonary metastases is described. The meningioma was an enormous hypervascular tumor with invasion of the superior sagittal sinus. The tumor was resected completely and histologically diagnosed as transitional meningioma. The Ki-67 labeling index was 5%. Four months after operation, the patient subsequently developed bilateral multiple lung lesions later identified as metastases. The lung lesions were partially removed surgically and histologically diagnosed as meningothelial meningioma WHO grade I. The Ki-67 labeling index was 2%. The histological findings demonstrated that the tumor occupied the arterial lumen and the perivascular space, suggesting that pulmonary tumors might metastasize via the vascular route. The histopathological features and mechanisms of metastasizing meningiomas are reviewed and discussed.

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“…Surgical resection allows seeded cells to access the blood and lymphatic system [9], however the more common reported route of metastasis is via invasion of the dural venous sinuses and cranial veins, with resultant spread into the pulmonary circulation, azygous and hemiazygous systems and vertebral venous plexus [10, 11]. This would account for the majority of sites for extracranial metastasis, most commonly being the lung and pleura (60%), and in order of decreasing frequency: liver, long bones, vertebrae, ribs, pleura, mediastinum, and lymph nodes [12, 13]. …”

Section: Discussionmentioning

confidence: 99%

Hepatic Metastasis via a Ventriculo-Peritoneal Shunt from an Intracranial Meningioma: Case Report and Review of the Literature

Moir¹,

Haugk

French³

2010

Case Rep Gastroenterol

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Meningiomas are slow-growing intracranial/intraspinal tumours, with a wide range of histopathological variants. The more aggressive atypical and malignant types can disseminate via the venous system, lymphatics or cerebrospinal fluid, with the lungs and pleura being the most common site of extracranial metastasis. We look at a 68-year-old woman presenting with abdominal pain, who had previously been treated for an intracranial meningioma with a ventriculo-peritoneal shunt in situ. Investigation revealed a lesion in segment 4 of the liver with the shunt tip being in close proximity. Biopsy was consistent with metastatic meningioma. A liver resection was subsequently performed. We postulate that this is the first reported case of dissemination of an intracranial meningioma via cerebrospinal fluid by means of a ventriculo-peritoneal shunt.

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LDH isoenzyme pattern in a meningioma with pulmonary metastases

Cited by 20 publications

References 5 publications

Metastatic meningioma detected in pleural fluid

Metastatic meningioma detected in pleural fluid

Multiple Pulmonary Metastases following Total Removal of a Bilateral Parasagittal Meningioma with Complete Occlusion of the Superior Sagittal Sinus: Report of a Case

Hepatic Metastasis via a Ventriculo-Peritoneal Shunt from an Intracranial Meningioma: Case Report and Review of the Literature

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