LDH Isoenzyme Pattern of Uninvolved Gastric Mucosa of Patients with Gastric Carcinoma and Benign Gastric Disease

Abstract

The LDH isoenzyme pattern of the uninvolved mucosa of gastric cancer patients differs as regards the LDH isoenzyme pattern from that of similar tissue of patients with benign gastric disease; the former tissue is characterised by a high M/H ratio of the LDH isoenzymes (M and H sub-units). A high M/H ratio characterises antral mucosa when the latter is compared with fundic mucosa. Mucosa showing superficial and atrophic gastritis also has a higher M/H ratio, whereas the presence of intestinal metaplasia does not appear to influence the M/H ratio. These observations are consistent with the concept that the tissue from which the cancer arose may possess a pre-malignant biochemical lesion.

Abnormal Lactic Dehydrogenase Patterns in Carcinoma of Stomach and in Peritumoral Tissues

“…On the other hand, our results match with those of Woollams et al (16) who found a high M/H ratio in the uninvolved mucosa of gastric cancer patients in association to gastritis. Latner et al (9) found in the morphological normal tissue which lies around the cervix, cancer an intermedium LDH isoenzyme between the normal and tumoral tissue.…”

Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

“…The authors deemed the altered LDHA to LDHB ratio as a possible biochemical indicator of an early process of malignant conversion [67]. These conclusions were supported by the data of other investigators who showed high LDHA to LDHB ratios in uninvolved tissues from resection edges that were related to local recurrence possibly due to deep infiltration [58,59,[68][69][70][71]. It is known that LDH-5 overproduction is related exclusively to cancer cells but not to stromal fibroblasts, which have low LDHA expression [72].…”

<i>β</i>-Glucuronidase and the Gastric Epithelial Cell

“…The well-established evidence relating to lactic acidosis (2,8,10,14,29,32,33) and changes in the LDH isoenzyme pattern with carcinoma (12,35) provides reasonable evidence that the change in (3-glucuronidase activity may also be an indication of malignancy.…”