LDH (Lactate Dehydrogenase): A Biochemical Marker for the Prediction of Adverse Outcomes in Pre-eclampsia and Eclampsia

Dave, Anupama; Maru, Laxmi; Jain, Astha

doi:10.1007/s13224-014-0645-x

Cited by 30 publications

(24 citation statements)

References 14 publications

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“…4 Lactate dehydrogenase (LDH) is an intracellular enzyme which converts lactic acid to pyruvic acid and its elevated levels indicates cellular death and leakage of enzyme from the cell .Increased levels of LDH were found in association with preeclampsia in a limited numbers of studies. 5 In Sudan there are many studies conducted among pregnant women suffering from pregnancy complication. [6][7][8][9] Present study is first one conducted among Sudanese women to examine the frequency symptoms occurring in severe preeclamptic patients according to the levels of GGT and LDH, indicating multiorgan involvement and severity of the disease.…”

mentioning

confidence: 99%

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Elias

Eltom

Osman

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks post-partum. Pre-eclampsia is a syndrome with multiple aetiologies which has made it difficult to develop adequate screening tests and treatments. Objective of this study to assess the level of gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia in Sudanese pregnant women.Methods: This is a case control hospitalize base study. The study was conducted in preeclamptic pregnant women in Omdurman maternity hospital and medical military hospital in Khartoum state. In this study glutamyl transferase and lactate de-hydrogenase was estimation in 100 Sudanese pregnant women by spectrophotometer method, 50 of them were diagnosed with preeclampsia 27 from this is severe preeclampsia and 23 is mild preeclampsia was matched in aged. Serum samples of all the cases were assayed for GGT and LDH. The data was recorded and analyzed using statistical package for social sciences (SPS –version 16) on programmed computer. The mean standard deviations of variable were calculated for both the test group and the control group and P value for comparison was obtained.Results: The mean values of plasma gamma glutamyl transferase in mild and severe preeclamptic pregnant women were insignificant difference when compared to control P value (0.346 - 0.089) respectively. The mean values of plasma lactate dehydrogenase in mild and severe preeclamptic pregnant women were significant increase when compared to control P value (0.008 - 0.001) respectively.Conclusions: The levels of LDH is raised in Sudanese pregnant women with hypertensive also can be useful biochemical marker that reflects the severity of and the occurrence of complications of pre-eclampsia. GGT levels were normal in Sudanese pregnant women with hypertensive preeclampsia.

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confidence: 99%

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Elias

Eltom

Osman

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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“…On analyzing the above data it is clearly observed that there is significant rise in the LDH levels with increasing severity of the disease (P <0.001) which was seen in studies done by Rajoria L et al, Dev SV et al and Bhave NV et al [13,14,15].…”

Section: Discussionmentioning

confidence: 64%

To study the correlation of serum lactate dehydrogenase (LDH) levels in women with preeclampsia on maternal and perinatal outcome

Siddiqui

2019

Obs Gyne Reivew J Obstet Gynecol

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Introduction: Pre-eclampsia is a multi-system disorder of unknown etiology and a major cause of maternal and perinatal complications. LDH is an intracellular enzyme and is increased when there is increased cell death. As pre-eclampsia leads to cellular death, so LDH levels can beused to assess the severity of disease. Aim: To study the correlation of levels of serum LDH in women with preeclampsia on maternal and perinatal outcome. Objectives: To correlate the maternal and perinatal outcomes with serum LDH levels. To assess serum LDH as a marker for severity of preeclampsia. Materials and Methods: A prospective comparative studywas conducted over a period of 18 months from November 2016 to April 2018 in the department of Obstetrics and Gynecology, Sri Siddhartha Medical Hospital, Tumakuru. Out of 180 women studied, 100 were normal pregnant women, 40 patients were having mild preeclampsia and 40 patients were having severe preeclampsia. The two groups and subgroups were studied based on age, gravidity, trimester, investigations, maternal and perinatal outcome, complications and follow up. Results: Higher values of LDH were found in mild and severe preeclamptic women than those of normal pregnant women in third trimester and was statistically significant. Severe lypreec lamptic patients had increased LDH levels which in association with investigations, outcome, complications and follow up was significant. Conclusion: LDH is a useful biochemical marker and can be considered as a supportive prognostic tool thatreflects the severity and complications of preeclampsia. Identification of high-risk patients, their close monitoring, and correct management may prevent these complications.

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“…In study by Nadkarni et al, 12 primigravida constituted 49% of total subjects in study group. Dave et al, 13 observed half of the cases in their study group as primigravida. Similar results were observed by Kheir et al 11 where 42% patients were primigravida.…”

Section: R E S U L T Smentioning

confidence: 77%

“…From this study, it can be concluded that elevated serum LDH level was associated with severity of pre-eclampsia. Dave A et al 13 conducted a study to find out the role of serum Lactate Dehydrogenase in prediction of adverse outcomes of pre-eclampsia and eclampsia i.e. severity of disease and occurrence of complications.…”

Section: Groupmentioning

confidence: 99%

To Study Levels of LDH in Normal Pregnancy, Pre-Eclampsia & Eclampsia

Kulkarni¹,

Shaikh²

2019

jemds

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BACKGROUND Hypertension during pregnancy is a major health problem. Hypertensive disorders of pregnancy (preeclampsia, eclampsia) are common medical complications and affect 10% pregnancies. These pregnancies are at increased risk for maternal complications like abruption, disseminated intravascular coagulation, HELLP syndrome, pulmonary oedema, stroke, hepatic failure and renal failure. Foetal complications include growth restriction, prematurity and death of foetus. Early screening of gestational hypertension and preeclampsia may reduce the maternal and foetal complications. METHODS We conducted this study of levels of LDH in normotensive pregnancy, preeclampsia and eclampsia. This is a hospital based comparative cross-sectional study conducted in the department of Obstetrics & Gynaecology, Bharati Vidyapeeth Medical College and Hospital, Sangli, from December 2015 to July 2017. Out of a total of 150 patients included in present study, 50 patients were in normotensive group, 50 in preeclampsia group and 50 were in eclampsia group. Along with blood investigations, LDH levels were studied in all three groups. RESULTS Mean LDH was 257.24 U/L in normotensive patients as compared to 417.84 U/L in patients with pre-eclampsia and 565.51 in patients with eclampsia. LDH levels were found to be raised in pre-eclampsia and eclampsia patients and was statistically significant. CONCLUSIONS Serum LDH is the earliest marker in blood during hypoxia and oxidative stress. It is raised in cases of pre-eclampsia and eclampsia. Detection of high-risk patients with increased levels of LDH mandates close monitoring, prompt and correct management to decrease both maternal and foetal morbidity and mortality. Estimation of serum Lactate Dehydrogenase can be used as a prognostic marker for preeclampsia and eclampsia.

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LDH (Lactate Dehydrogenase): A Biochemical Marker for the Prediction of Adverse Outcomes in Pre-eclampsia and Eclampsia

Cited by 30 publications

References 14 publications

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

To study the correlation of serum lactate dehydrogenase (LDH) levels in women with preeclampsia on maternal and perinatal outcome

To Study Levels of LDH in Normal Pregnancy, Pre-Eclampsia & Eclampsia

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