LDH Level in Acute Organophosphorus Poisoning and Its Relation With Severity and Mortality: A Tertiary Care Hospital Experience

Abstract

Background: Organophosphorus compounds have been widely used for a few decades in agriculture for crop protection and pest control. In India Organophosphorus poisoning is the most common. The objective of our study was to measure the LDH Level in acute organophosphorus poisoning
 Methods: This study was conducted among minimum 100 patients acute organophosphorus poisoning admitted in Casualty ward, MICU and attending medical ward of JLN hospital, Ajmer during Aug 2018 to July 2020. Serum lactate dehydrogenase estimation by spectrophotometric analysis using Beckman Coalter AU 680
 Results: These were significantly higher among deaths on day 1 and 3(810±372.99 and 1027.09±458.26, respectively) in comparison to survivors on day 1 and 3 (538.18±300.42 and 365.19±175.49, respectively). Significant difference was found between mean values of different levels of severity of LDH on day 1 and 3.
 Conclusion: In conclusion, this study found that Serum LDH can be used as biomarker in diagnosis or stratifying severity of acute OP poisoning, as it is cheap and easily available, especially in developing countries. Serial measurements of serum LDH levels in acute OP poisoning can predict the prognosis.
 Keywords: LDH, OP poisoning, Severity

Mean Serum Creatine Kinase among Organophosphate Poisoning Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study

“…11,12 Another tissue injury marker, LDH has also been reported to be elevated in organophosphate poisoning in many studies. 7,13 Creatine kinase (81 kDa) being of lower molecular weight than lactate dehydrogenase (144 kDa) may be the reason for its spillage into the blood faster, thus the early indicator of tissue damage. 14 This study is based on laboratory findings in diagnosed cases of organophosphorus poisoning.…”