LDI-MS performance of gold nanostars as an inorganic matrix for low molecular weight analytes

Sagandykova, Gulyaim; Pryshchepa, Oleksandra; Rafińska, Katarzyna; Mametov, Radik; Madajski, Piotr; Pomastowski, Paweł

doi:10.1016/j.ijms.2022.116872

Cited by 10 publications

(9 citation statements)

References 50 publications

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“…Extra element doping has been proven to be a good solution, especially the introduction of noble metal nanoparticles, which offer abundant plasmonic hot spots for carrying charges and accelerating charges transfer, on account of their inherent surface plasmon resonance effect. 25,26 As well known, the low abundance of cancer-derived exosomes and the complexity of body fluids bring great difficulties to the isolation of specific exosomes, and extra signal amplification strategies or delicate instruments with high cost are usually required. 27−32 Consequently, huge obstacles exist when promoting specific exosomes to large-scale clinical applications.…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, the single component presents an insufficient charge transfer rate that is not enough to provide strong ionization efficiency toward metabolites for practical clinical uses. Extra element doping has been proven to be a good solution, especially the introduction of noble metal nanoparticles, which offer abundant plasmonic hot spots for carrying charges and accelerating charges transfer, on account of their inherent surface plasmon resonance effect. , …”

Section: Introductionmentioning

confidence: 99%

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Exosome Metabolic Patterns on Aptamer-Coupled Polymorphic Carbon for Precise Detection of Early Gastric Cancer

Chen

Huang

et al. 2022

ACS Nano

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Gastric cancer (GC) presents high mortality worldwide because of delayed diagnosis. Currently, exosome-based liquid biopsy has been applied in diagnosis and monitoring of diseases including cancers, whereas disease detection based on exosomes at the metabolic level is rarely reported. Herein, the specific aptamer-coupled Au-decorated polymorphic carbon (CoMPC@Au-Apt) is constructed for the capture of urinary exosomes from early GC patients and healthy controls (HCs) and the subsequent exosome metabolic pattern profiling without extra elution process. Combining with machine learning algorithm on all exosome metabolic patterns, the early GC patients are excellently discriminated from HCs, with an accuracy of 100% for both the discovery set and blind test. Ulteriorly, three key metabolic features with clear identities are determined as a biomarker panel, obtaining a more than 90% diagnostic accuracy for early GC in the discovery set and validation set. Moreover, the change law of the key metabolic features along with GC development is revealed through making a comparison among HCs and GC at early stage and advanced stage, manifesting their monitoring ability toward GC. This work illustrates the high specificity of exosomes and the great prospective of exosome metabolic analysis in disease diagnosis and monitoring, which will promote exosome-driven precision medicine toward practical clinical application.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exosome Metabolic Patterns on Aptamer-Coupled Polymorphic Carbon for Precise Detection of Early Gastric Cancer

Chen

Huang

et al. 2022

ACS Nano

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“…As alternatives to traditional matrixes, researchers have proposed metal/metal oxide-based ( Sakurai et al., 2018 ; Sagandykova et al., 2022 ), carbon-based ( Xu et al., 2021 ), and silicon-based ( Dou et al., 2022 ) matrixes. Metal particles with nanoscale diameters are of interest due to their unique plasmon absorption in the visible region, in which gold nanoparticles (Au NP) and silver nanoparticles (Ag NP) are the often utilized metal matrixes.…”

Section: Introductionmentioning

confidence: 99%

Prefabricated platinum nanomaterial matrix for MALDI-MS imaging of oligosaccharides and lipids in plant tissues

et al. 2023

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Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) can visualize the spatial distribution characteristics of molecules in tissues in situ, in which the matrix plays a key role. In this paper, we propose a platinum nanomaterial pre-coated matrix, which can be prepared in bulk by sputtering platinum nanoparticles onto slides using an ion sputterer and then used for MALDI-MS analysis by placing tissue sections on the matrix. We used this matrix for MALDI-MS imaging analysis of corn kernels and germinated wheat sections, and the results show that triacylglycerides were mainly distributed in the embryo of corn kernels and germinated wheat, and sugars were mainly distributed in the endosperm, with the highest content of disaccharides.It provides a simple and reliable experimental condition for analyzing the distribution of oligosaccharide and lipid components in plant tissues.

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“…18,19 The colorimetric response of such test strips is caused by the surface plasmon resonance phenomenon in which the surface plasma of AuNPs changes and shifts in resonance wavelength, 20 offering a "yes/no" result for diagnosis. Furthermore, AuNPs have been used as a direct matrix for laser desorption ionization-mass spectrometry (LDI-MS), 21 which is a soft ionization-mass spectrometry technique that can be utilized for sensitive and quantitative measurement. 22,23 Hence, to achieve accurate quantitative information, LDI-MS was selected to directly couple with an AuNP-based colorimetric sensor without sample preparation and matrix requirements.…”

Section: Introductionmentioning

confidence: 99%

Alternative platform for COVID-19 diagnosis based on AuNP-modified lab-on-paper

Punnoy

Siripongpreda

Pisitkun

et al. 2023

Analyst

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LDI-MS performance of gold nanostars as an inorganic matrix for low molecular weight analytes

Cited by 10 publications

References 50 publications

Exosome Metabolic Patterns on Aptamer-Coupled Polymorphic Carbon for Precise Detection of Early Gastric Cancer

Exosome Metabolic Patterns on Aptamer-Coupled Polymorphic Carbon for Precise Detection of Early Gastric Cancer

Prefabricated platinum nanomaterial matrix for MALDI-MS imaging of oligosaccharides and lipids in plant tissues

Alternative platform for COVID-19 diagnosis based on AuNP-modified lab-on-paper

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