LDL adsorbent with dendrimer PAMAM as spacer

Abstract

Dendritic polymers are three-dimensional, highly ordered compounds formed by reiterative reaction sequences, and via discrete stages referred to as generations. To study the spacer effect of low density lipoprotein (LDL) adsorbent, we linked dendrimer polyamidoamine (PAMAM) generation 1 (G1), generation 3 (G3) and generation 5 (G5) to cellulose beads, respectively, and then determined the adsorption proportion of the adsorbents with PAMAM decorated with taurine. The result shows that the spacer with activated multi-points could efficiently improve the adsorption capacity of the adsorbent.

Adsorbents in blood purification: From lab search to clinical therapy

“…The autoclave and storage test showed the adsorbent was stable [22]. Cellulose based LDL adsorbent with taurine functional group and PAMAM spacer also showed high adsorption capacity for LDL [23].…”