LDL electronegativity index: a potential novel index for predicting cardiovascular disease

Ivanova, Ekaterina A.; Bobryshev, Yuri V.; Orekhov, Alexander N.

doi:10.2147/vhrm.s74697

Cited by 18 publications

(10 citation statements)

References 97 publications

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“…Similarly, linear trend analysis and logistic regression models confirmed that although obese adolescents had more LDL(-), the variability was not explained by lipid parameters monitored in this study, except for a significant linear trend with BMI and WC. This possibility was shown in a recent review performed by Ivanova et al, which proposed LDL(-) as an independent cardiovascular risk factor 33 . In contrast, Hsu et al identified associations between LDL(-) and multiple cardiovascular risks, suggesting that this particle can be used as a novel cardiovascular risk factor 34 .…”

Section: Discussionmentioning

confidence: 88%

Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents

Freitas

Fernandez

Cohen

et al. 2018

Clinics

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OBJECTIVES:To evaluate biomarkers associated with early cardiometabolic risk in obese adolescents.METHODS:This cross-sectional study included 137 adolescents of both sexes aged 10 to 19 years divided into a normal weight group (NW) (n=69) and an obese group (OB) (n=68).RESULTS:As expected, obesity showed positive associations with homeostatic model assessment for insulin resistance (HOMA-IR), triacylglycerol, insulin, plasma levels of non-esterified fatty acids, and cholesterol ester transfer protein activity and negative associations with plasma antioxidant levels. Plasma oxidized low-density lipoprotein (oxLDL) and electronegative low-density lipoprotein [LDL(-)] levels were significantly higher in the OB group. Higher tertiles of oxLDL were associated with increased values of body mass index; waist circumference; fatty mass percentage (%FM); and the atherogenic lipids non-high-density-lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B and triacylglycerol. Higher tertiles of LDL(-) were robustly associated with body mass index and waist circumference. Logistic regression models (odds ratios) confirmed that increased values of lipids and apolipoprotein B were associated with increased risk of oxLDL. For LDL(-), these associations were not significant, suggesting that another mechanism is involved in generating this particle in obese adolescents.CONCLUSIONS:Obese adolescents showed increased plasma LDL(-) and oxLDL, and obese girls had more LDL(-) than obese boys. Therefore, oxLDL is strongly and independently associated with classical cardiovascular risk factors, while increased levels of LDL(-) were influenced by body mass index, waist circumference and demographic parameters in obese adolescents.

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Section: Discussionmentioning

confidence: 88%

Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents

Freitas

Fernandez

Cohen

et al. 2018

Clinics

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“…It has been suggested that increased oxidative stress may account for the formation of atherogenic oxidized LDL and that the modified particle can trigger the development of the immune response and induce lipid accumulation in the arterial wall [ 80 ]. Studying of LDL composition of blood plasma of atherosclerotic patients revealed different types of LDL modification, including desialylation, glycation, acquisition of negative electric charge, and complex formation [ 81 ]. Complex formation renders modified LDL particles especially atherogenic.…”

Section: Foam Cell Formationmentioning

confidence: 99%

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

Bobryshev

Ivanova

Chistiakov

et al. 2016

BioMed Research International

301

203

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Atherosclerosis can be regarded as a chronic inflammatory state, in which macrophages play different and important roles. Phagocytic proinflammatory cells populate growing atherosclerotic lesions, where they actively participate in cholesterol accumulation. Moreover, macrophages promote formation of complicated and unstable plaques by maintaining proinflammatory microenvironment. At the same time, anti-inflammatory macrophages contribute to tissue repair and remodelling and plaque stabilization. Macrophages therefore represent attractive targets for development of antiatherosclerotic therapy, which can aim to reduce monocyte recruitment to the lesion site, inhibit proinflammatory macrophages, or stimulate anti-inflammatory responses and cholesterol efflux. More studies are needed, however, to create a comprehensive classification of different macrophage phenotypes and to define their roles in the pathogenesis of atherosclerosis. In this review, we provide an overview of the current knowledge on macrophage diversity, activation, and plasticity in atherosclerosis and describe macrophage-based cellular tests for evaluation of potential antiatherosclerotic substances.

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“…Moreover, the desialylated LDL subfraction was more electronegative than native LDL [36]. Additionally, there was a direct correlation between LDL being electronegative (LDL(−)) and its desialylation rate suggesting that desialylated LDL and LDL(−) may belong to the same LDL subfraction [33,37]. In healthy subjects, the LDL(−) subfraction was shown to be highly enriched with desialylated LDL, which had a substantial reduction of sialic acid content, compared to native LDL [31,38,39,40].…”

Section: The Concept Of Multiple Modifications Of Ldl In Atherogenmentioning

confidence: 99%

The Atherogenic Role of Circulating Modified Lipids in Atherosclerosis

Summerhill

Grechko

Yet

et al. 2019

IJMS

116

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Lipid accumulation in the arterial wall is a crucial event in the development of atherosclerotic lesions. Circulating low-density lipoprotein (LDL) is the major source of lipids that accumulate in the atherosclerotic plaques. It was discovered that not all LDL is atherogenic. In the blood plasma of atherosclerotic patients, LDL particles are the subject of multiple enzymatic and non-enzymatic modifications that determine their atherogenicity. Desialylation is the primary and the most important atherogenic LDL modification followed by a cascade of other modifications that also increase blood atherogenicity. The enzyme trans-sialidase is responsible for the desialylation of LDL, therefore, its activity plays an important role in atherosclerosis development. Moreover, circulating modified LDL is associated with immune complexes that also have a strong atherogenic potential. Moreover, it was shown that antibodies to modified LDL are also atherogenic. The properties of modified LDL were described, and the strong evidence indicating that it is capable of inducing intracellular accumulation of lipids was presented. The accumulated evidence indicated that the molecular properties of modified LDL, including LDL-containing immune complexes can serve as the prognostic/diagnostic biomarkers and molecular targets for the development of anti-atherosclerotic drugs.

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LDL electronegativity index: a potential novel index for predicting cardiovascular disease

Cited by 18 publications

References 97 publications

Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents

Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

The Atherogenic Role of Circulating Modified Lipids in Atherosclerosis

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