LDL oxidada, lipoproteína(a) y otros factores de riesgo emergentes en el infarto agudo de miocardio (estudio FORTIAM)

Gómez, Miquel; Valle, Vicente; Arós, Fernando; Sanz, Ginés; Sala, Joan; Fiol, Miquel; Bruguera, Jordi; Elosúa, Roberto; Molina, Lluís; Martí, Helena; Covas, María Isabel; Rodríguez-Llorián, Andrés; Fitó, Montserrat; Suárez-Pinilla, M.A.; Amézaga, Rocío; Marrugat, Jaume

doi:10.1016/s0300-8932(09)70894-2

Cited by 22 publications

(3 citation statements)

References 28 publications

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“…Up until the present day, very little is known about Lp(a) as a risk predictor for MACE after AMI events nor its incorporation to the existing scoring systems. [6][7][8] Over the past few decades, various types of clinical risk stratification have been introduced to assess and classify patient's risk so that high-risk AMI patients could be advised to have an early revascularization. Some well-known tools came from the glycoprotein IIb/IIIa in Platelet Unstable angina: Receptor Suppression Using Integrilin Therapy (PURSUIT), Thrombolysis in Myocardial Infarction (TIMI) and the Global Registry of Acute Cardiac Events (GRACE).…”

Section: Introductionmentioning

confidence: 99%

<p>High Lipoprotein(a) Levels as a Predictor of Major Adverse Cardiovascular Events in Hospitalized-Acute Myocardial Infarction Patients</p>

Sumarjaya¹,

Nadha²,

Lestari³

2020

VHRM

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Video abstractPoint your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use:https://youtu.be/LUESRF3ZdccBackground: Risk stratification models with incorporation of biochemical markers have received attention recently. In acute myocardial infarction (AMI) one such marker is lipoprotein(a) (Lp(a)). Lp(a) has prothrombotic and proinflammatory properties. High levels of Lp(a) probably contribute to the additional adverse effects in AMI, as it enhances the damaging effect of acute thrombosis. This study aimed to evaluate serum Lp(a) as a predictor of major adverse cardiovascular events (MACE) in hospitalized-acute myocardial infarction patients. Methods: A prospective cohort study was conducted at Sanglah Hospital, Denpasar, during June-August 2018, among 66 people by consecutive sampling. Samples that met the inclusion and exclusion criteria were examined for serum Lp(a) at the time of admission and the occurrence of MACE during hospitalization was observed. Data regarding serum Lp(a), demography, smoking history, dyslipidemia, hypertension, diabetes mellitus, and MACE were collected. Log rank test and Cox proportional hazards regression were conducted with SPSS version 20 for Windows. Results: During observation, MACE occurred in 25 (38%) patients, including cardiogenic shock in 7 (10.6%) patients, heart failure in 20 (30.3%) patients, cardiovascular death in 5 (7, 6%) patients, malignant arrhythmias in 5 (7.6%) patients, and postinfarction angina in 5 (7.6%) patients. After the Log rank test, a significant difference in survival was observed (p = 0.001) between groups of high Lp(a) (survival rate of 60.6 hours; 95% CI 43.3-77.9) and low Lp(a) (average survival of 104.3 hours, 95% CI 91.4-117.2). The hazard ratio of high Lp(a) against MACE was 4.63 (p=0.002), and it increased to 4.69 in multivariate analysis with Cox proportional hazards regression test (p=0.003). Conclusion: The high level of Lp(a) in AMI patients was a risk factor for the occurrence of MACE during hospitalization. Patients with high Lp(a) also had worse survival compared to patients with low Lp(a).

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Section: Introductionmentioning

confidence: 99%

<p>High Lipoprotein(a) Levels as a Predictor of Major Adverse Cardiovascular Events in Hospitalized-Acute Myocardial Infarction Patients</p>

Sumarjaya¹,

Nadha²,

Lestari³

2020

VHRM

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“…It is widely accepted that LDL oxidation is a starting point of the arterial injury (Bunout et al 2000;Sutherland et al 2007). The last comments have helped to explain the relationship between nutrition, atherosclerosis and coronary risk (Gómez et al 2009). Therefore, a diet based on fruits and vegetables with a high content of phenolic compounds could have a therapeutic potential to protect the endothelium from oxidative stress and atherogenesis caused by oxidized LDL (Ruel et al 2008;Quiñones et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Tropical fruits polyphenols: inhibitors of the oxidation of the LDL

Herrera-Pérez

Fernández-Acosta

Bebelagua

et al. 2022

Preprint

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The antioxidant power of the polyphenols of some tropical fruits such as the papaya (Carica papaya L.), soursop (Annona muricata L.), mammee (Pouteria sapota (Jacq.) H.E. Moore & Stearn), guava (Psidium guajava L.), banana cv. Vietnamese (Musa paradisiaca L.) and tamarind (Tamarindus indicus L.) were evaluated. The oxidation was performed at 37 °C with different concentrations of polyphenols. The oxidation products were measured by the 2-tiobarbituric acid method. The IC50 and Antioxidant Potential per Serving (APS) were estimated as an antioxidant quality indexes. The estimated IC50 values (µM) were: 21.3 (papaya); 21.5 (soursop); 22.4 (banana); 19.1 (guava); 14.7 (mammee) and 12.9 (tamarind). The APS values were: 20.2 (papaya); 51.6 (soursop); 37 (banana); 83 (guava); 30.3 (mammee) and 218 (tamarind). All fruit polyphenols inhibit the LDL oxidation. The polyphenols of tamarind and mammee presented the best antioxidant quality, while the tamarind and guava showed the biggest APS.

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“…( Lendon CL et al 1991;Davies MJ et al 1993;WC, JD, et al, 2007) Más recientemente, la lipoproteína de baja densidad oxidada (LDLox), la cual está involucrada directamente en la formación de la placa de ateroma, ha sido asociada al proceso de inestabilidad y extensión de la aterosclerosis coronaria. (Meisinger, 2005;Armstrong E, 2006) Sin embargo, existen pocos datos clínicos que la relacionen con el pronóstico tras un síndrome coronario agudo (Gómez M et al, 2009).…”

Section: Introductionunclassified

Evaluación de la actividad antioxidante de los extractos obtenidos con co2 supercrítico a partir de residuos de la industria de palma de aceite (elaeis gineensis yaq)

Piedrahita¹

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Esta investigación está enmarcada en el área de lípidos y salud y su objetivo fue recuperar sustancias de alto valor como tocoferoles y tocotrienoles mediante extracción con CO2 súper crítico (SFE CO2) a partir de subproductos de la industria de aceite de Palma. Las Hojas y fibras residuales de la producción de aceite de palma son una buena fuente de vitamina E, ya que contienen más de 5 % de aceite residual, con 2000 ppm de vit. E.

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LDL oxidada, lipoproteína(a) y otros factores de riesgo emergentes en el infarto agudo de miocardio (estudio FORTIAM)

Cited by 22 publications

References 28 publications

<p>High Lipoprotein(a) Levels as a Predictor of Major Adverse Cardiovascular Events in Hospitalized-Acute Myocardial Infarction Patients</p>

<p>High Lipoprotein(a) Levels as a Predictor of Major Adverse Cardiovascular Events in Hospitalized-Acute Myocardial Infarction Patients</p>

Tropical fruits polyphenols: inhibitors of the oxidation of the LDL

Evaluación de la actividad antioxidante de los extractos obtenidos con co2 supercrítico a partir de residuos de la industria de palma de aceite (elaeis gineensis yaq)

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