LDL particle heterogeneity, and its association with other established cardiovascular risk factors in a young Indian industrial population

Prabhakaran, Dorairaj; Tarik, Mohamad; Gupta, Ruby; Reddy, K. Srinath

doi:10.1136/heartasia-2012-010130

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…Also, Notarnicola et al [ 30 ] showed that higher concentrations of sdLDL would increase the risk of mortality in patients with CVDs. In line with the two studies mentioned, other studies reported similar results [ 24 , 25 , 31 – 34 ]. Further, some studies have specifically examined the association between LDL subtypes and the incidence of various cardiovascular diseases.…”

Section: Resultssupporting

confidence: 87%

Association of LDL-cholesterol subfractions with cardiovascular disorders: a systematic review

Chary,

Tohidi,

Hedayati

2023

BMC Cardiovasc Disord

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Background Cardiovascular disorders (CVDs) are the leading cause of death worldwide. This study aimed to evaluate the association between low-density lipoprotein (LDL) subfractions and cardiovascular disorders. Methods To ensure the rigor of the systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. For this systematic review, a comprehensive search strategy was performed in important databases including PubMed, Scopus, Embase, International Statistical Institute (ISI) Web of Science, and google scholar from 2009 to February 2021. The following terms were used for systematic search: low-density lipoprotein, LDL, subfractions, subclasses, nuclear magnetic resonance, NMR, chromatography, high-pressure liquid, HPLC, cardiovascular disease, cerebrovascular, and peripheral vascular disease. Also, for evaluating the risk of bias, the Newcastle-Ottawa scale was employed. Results At the end of the search process, 33 articles were included in this study. The results of most of the evaluated studies revealed that a higher LDL particle number was consistently associated with increased risk for cardiovascular disease, independent of other lipid measurements. Also, small dense LDL was associated with an increased risk of CVDs. There was no association between LDL subfraction and CVDs in a small number of studies. Conclusions Overall, it seems that the evaluation of LDL subclasses can be used as a very suitable biomarker for the assessment and diagnosis of cardiovascular diseases. However, further studies are required to identify the mechanisms involved.

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Section: Resultssupporting

confidence: 87%

Association of LDL-cholesterol subfractions with cardiovascular disorders: a systematic review

Chary,

Tohidi,

Hedayati

2023

BMC Cardiovasc Disord

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show abstract

“…Also, Notarnicola et al (30) showed that higher concentrations of sdLDL increase the risk of mortality in patients with CVDs. In line with the two studies mentioned, other studies reported similar results (24,25,(31)(32)(33)(34). Also, some studies have speci cally examined the association between LDL subtypes and the incidence of various cardiovascular diseases.…”

Section: Characteristics Of the Included Studiessupporting

confidence: 71%

Association of LDL-cholesterol subtractions with cardiovascular disorders: A systematic review

Chary

Tohidi

Hedayati

2023

Preprint

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Background: Cardiovascular disorders (CVDs) are the leading cause of death worldwide. This study aimed to evaluate the association between Low-Density Lipoprotein (LDL) subfractions and cardiovascular disorders. Methods: For to ensure the rigor of the systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. For this systematic review, a comprehensive search strategy in important databases including PubMed, Scopus, Embase, International Statistical Institute (ISI) Web of Science and google scholar from 2009 to February 2021 was performed. Also, for the evaluation of the risk of bias, the Newcastle-Ottawa scale was used. Results: At the end of the search process, 33 articles were included in this study. The results of more of the evaluated studies were shown that the higher LDL particle number was consistently associated with increased risk for cardiovascular disease, independent of other lipid measurements. Also, small dense LDL was associated with an increased risk of CVDs. There wasn’t any association between LDL subfraction with CVDs in a small number of studies. Conclusions: Overall, it seems that the evaluation of LDL subclasses can be used as a very suitable biomarker for the evaluation and diagnosis of cardiovascular diseases. However, further studies are needed to identify the mechanisms involved.

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“…However individuals with LDL-C levels within the normal range can also develop atherosclerosis and CVD (61) . This variation in risk is thought to be due to the heterogeneity of these LDL particles with regards to their size, density and chemical composition (62) . Higher concentration of small, dense LDL-P is associated with an increased risk of CVD, independent of overall LDL-C levels (63) .…”

Section: Traditional V Newer Risk Markers Of Cvdmentioning

confidence: 99%

The effects of saturated fat intake from dairy on CVD markers: the role of food matrices

Dunne,

Gibney,

McGillicuddy

et al. 2024

Proc. Nutr. Soc.

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CVD is the leading cause of death worldwide, and is commonly associated with modifiable risk factors. Most studies to date examining link between food intake and risk of CVD, have focused on modulation of plasma cholesterol concentrations (total cholesterol (TC), LDL-C). However, recent studies suggest LDL particle size is a more sensitive risk marker for CVD with smaller, dense LDL particles reported as more atherogenic than larger, more buoyant LDL. Although dietary guidelines recommend SFA intake of < 10 % of total energy, this does not consider food source, with recent evidence suggesting differing, sometimes beneficial, lipid responses following consumption of SFA from dairy compared to other food sources. This may be from differences in the physical food matrices, the nutrient content of the foods, and/or how these components interact with each other, described as a ‘dairy matrix effect’. Dietary fat not only raises LDL-C, but also HDL cholesterol (HDL-C), associated with reduced CVD risk. HDL particles are complex emulsions of lipids, proteins and microRNAs that exhibit atheroprotective properties. In addition, HDL particles exhibit a very heterogeneous proteomic composition, dependent on a person’s disease state – with a more pro-inflammatory proteome evident in patients with established CVD. This review will discuss the evidence to date on the importance of the food matrix in modulating response to dietary SFA and impact on CVD risk factors. A focus on potential biomarker properties of lipoprotein particles beyond cholesterol and current use of such biomarkers in human nutrition research will be considered.

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LDL particle heterogeneity, and its association with other established cardiovascular risk factors in a young Indian industrial population

Cited by 6 publications

References 27 publications

Association of LDL-cholesterol subfractions with cardiovascular disorders: a systematic review

Association of LDL-cholesterol subfractions with cardiovascular disorders: a systematic review

Association of LDL-cholesterol subtractions with cardiovascular disorders: A systematic review

The effects of saturated fat intake from dairy on CVD markers: the role of food matrices

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