LDL size and subclass pattern in a biethnic population.

Haffner, Steven M.; Mykkänen, Leena; Valdéz, Rodolfo; Paidi, Michael; Stern, Michael P.; Howard, Barbara V.

doi:10.1161/01.atv.13.11.1623

Cited by 65 publications

(31 citation statements)

References 41 publications

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“…However, triglycerides returned to baseline values at study week 24. In other populations, serum triglycerides are inversely related to LDL particle size (18,27). In our subjects, decreases in triglycerides were associated with a favorable increase in LDL particle size (r ϭ Ϫ0.59, P ϭ 0.001).…”

Section: Discussionsupporting

confidence: 52%

Metabolic effects of nandrolone decanoate and resistance training in men with HIV

Sattler

Schroeder

Dubé

et al. 2002

American Journal of Physiology-Endocrinology and Metabolism

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-Thirty human immunodeficiency virus (HIV)-infected men were randomized to a high dose of nandrolone decanoate weekly (group 1) or nandrolone plus resistance training (group 2) for 12 wk. For the two groups, nandrolone had no significant effects on total cholesterol, LDL cholesterol, LDL phenotype, or fasting triglycerides, although triglycerides decreased by 66 Ϯ 124 mg/dl for the entire population (P ϭ 0.01). Group 2 subjects had a favorable increase of 5.2 Ϯ 7.7Å in LDL particle size (P ϭ 0.03), whereas there was no change in group 1. Lipoprotein(a) decreased by 7.3 Ϯ 6.8 mg/dl for group 1 (P ϭ 0.002) and by 6.9 Ϯ 8.1 for group 2 (P ϭ 0.013). However, HDL cholesterol decreased by 8.7 Ϯ 7.4 mg/dl for group 1 (P Ͻ 0.001) and by 10.6 Ϯ 5.9 for group 2 (P Ͻ 0.001). Percentages of HDL 2b (9.7-12 nm) and HDL2a (8.8-9.7 nm) subfractions decreased similarly for the two groups, whereas HDL 3a (8.2-8.8 nm) and HDL3b (7.8-8.2 nm) increased in the groups during study therapy (P Յ 0.02 for all comparisons). There was no evidence of a decreased insulin sensitivity in either group, whereas fasting glucose, fasting insulin, and homeostasis model assessment improved in group 2 (P Ͻ 0.05). These metabolic effects were favorable (other than for HDL), but changes were generally transient (except for HDL in group 2), with measurements returning to baseline 2 mo after the interventions were completed. anabolic steroids; lipoprotein(a); androgen therapy; insulin resistance; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; serum triglycerides THE PRINCIPAL USE of supplemental testosterone therapy is to restore eugonadal hormone levels in men with primary or secondary hypogonadism. However, treatment with androgens, including semisynthetic derivatives of testosterone, also has positive anabolic effects in subjects with cachexia due to severe burns (16), renal failure (32), chronic lung disease (51), cancer (13), and alcoholic hepatitis (44). Androgens also promote synthesis of myofibrillar proteins (53, 59) and are attractive therapies for sarcopenia in older individuals with frailty (19, 56). Thus it is likely that androgens will be further tested for a broad range of medical conditions.Androgens can also influence lipid and carbohydrate metabolism in both men and women. These effects include reductions in plasma triglycerides (30), HDL cholesterol (7,21,55), and lipoprotein(a) [Lp(a)] (41

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Section: Discussionsupporting

confidence: 52%

Metabolic effects of nandrolone decanoate and resistance training in men with HIV

Sattler

Schroeder

Dubé

et al. 2002

American Journal of Physiology-Endocrinology and Metabolism

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“…Triglyceride concentrations predict by 60% the size of LDL [8]. Other parameters related to LDL size were tested in our work.…”

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confidence: 99%

SNP3 polymorphism in apo A-V gene is associated with small dense LDL particles in Type 2 diabetes

et al. 2004

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“…The fasting plasma insulin concentration correlates positively with whole plasma and VLDL triglycerides and negatively with HDL cholesterol even in multivariate analyses controlled for important confounders such as age, sex, glucose tolerance, obesity and body fat distribution. Population-based studies have also reported associations between fasting plasma insulin and lipoprotein subclasses such as the inverse relations to the LDL peak particle size [4] and the HDL 2 cholesterol concentration [5]. Furthermore, the plasma insulin concentration has proved to be related to the production of large VLDL particles with a Svedberg flotation (Sf) rate of 60 to 400 in experimental studies in humans using a stable isotope technique [6].…”

mentioning

confidence: 99%

Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men

et al. 2000

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A cluster of risk factors for Type II (non-insulin-dependent) diabetes mellitus and cardiovascular disease, called the metabolic syndrome, is a common feature of otherwise healthy people living in industrialised countries. Increased visceral adipose tissue depots, insulin resistance with ensuing hyperinsulinaemia and dyslipoproteinaemia including hypertriglyceridaemia, a low HDL cholesterol concentration and a preponderance of small, dense LDL particles are central components of this syndrome [1]. The links between glucose-insulin homeostasis and lipoprotein metabolism have received particular atten- Abstract Aims/hypothesis. Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-aged men. Methods. The subjects, 99 healthy 50-year-old men with an apolipoprotein E3/3 genotype, ate a mixed meal. The apolipoprotein B-48 and B-100 contents were determined in triglyceride-rich lipoproteins as a measure of chylomicron remnant and very low density lipoprotein particle concentrations. Results. Fasting plasma insulin was associated with the triglyceride response to the test meal, independently of body mass index, waist-to-hip circumference ratio, blood glucose and the insulin effect on fasting plasma triglycerides. Exaggerated and prolonged postprandial lipaemia in subjects in the upper quartile of the plasma insulin distribution was largely accounted for by large (Svedberg flotation rate > 60) very low density lipoproteins and chylomicron remnants. Insulin relations to large postprandial triglyceride-rich lipoproteins exclusively reflected the association between plasma insulin and the fasting plasma concentrations of these lipoprotein species, whereas plasma insulin and late postprandial plasma concentrations of small (Svedberg flotation rate 20±60) chylomicron remnants were related, independently of insulin influences on fasting concentrations. Strong positive relations were found between the late increases in large triglyceride-rich lipoproteins and plasma non-esterified fatty acid concentrations after 6 h. Conclusion/interpretation. The degree of insulin sensitivity is a major determinant of postprandial lipaemia in healthy middle-aged men and could add to the regulation of the basal production of large triglyceride-rich lipoproteins. [Diabetologia (2000)

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LDL size and subclass pattern in a biethnic population.

Cited by 65 publications

References 41 publications

Metabolic effects of nandrolone decanoate and resistance training in men with HIV

Metabolic effects of nandrolone decanoate and resistance training in men with HIV

SNP3 polymorphism in apo A-V gene is associated with small dense LDL particles in Type 2 diabetes

Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men

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