Le biguanidi nel trattamento dell'obesita'. Nota 1. Ricerca clinica controllata con placebo, anoressanti, fenformina e metformina

Cucurachi, L; Strata, A; Zuliani, U; Cucurachi, P; Dell'Anna, A

doi:10.1007/bf01545359

Cited by 4 publications

(1 citation statement)

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“…The insulin response and the insulin/glucose ratios on the other hand were significantly decreased after treatment, suggesting a greater effectiveness of insulin. Results reported in the literature concerning influence of long-term metformin treatment [8,15] are difficult to interpret in view of reduction in body weight, which by itself improves glucose assimilation. Most studies on the influence of biguanides on plasma glucose and insulin levels were performed in obese, mildly diabetic patients [2,20] and the decrease in insulin levels might be considered to be a consequence of the hypoglyeaemie effect of biguanides observed in these patients.…”

Section: Discussionmentioning

confidence: 99%

Influence of dimethylbiguanide (metformin�) on carbohydrate metabolism in obese, non-diabetic women

Vermeulen

Rottiers

1972

Diabetologia

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The authors have studied the influence of 2 weeks' treatment of 15 non-diabetic, obese subjects with 2 g of Metformin daily, on intravenous glucose tolerance and plasma insulin levels. Blood glucose fasting and during the IVGTT were not influenced by treatment, but the insulin levels and the insulin/glucose ratios were significantly decreased. This points to a decreased insulin resistance. Influence du traitement d la Metformine sur le mgtabolisme glucidique chez des femmes ob~ses non diabdtiques Rdsumd. Les auteurs ont dtudid chez 15 obbses non diabdtiques, l'infiuence d'un traitement ~ la Metformine (2 g/ jour pendant quinze jours) sur la glycdmie e$ le taux d'insulindmie ~ jeun et apr~s une surcharge glucosde intraveineuse. Le traitement n'infiuence ni la glyc6mie ~ jeun, ni la glyc6mie aprbs surcharge intraveineuse ni la constantc d'assimflation du glucose. L'insulindmie ~ jeun et aprbs surcharge glueosde est cependant nettement diminude, de m6me que le rapport insulindmid/glycdmie. Ceei semble indiquer une rdduction de la rdsistance l'insuline observde chez les obbses non diabdtiques. Zusammenfassung. Die Autoren untersuchten an 15 iibergewichtigen, nieht diabetischen Patienten die Beeinflussung des Kohlenhydratstoffwechsels und der Insulin-Sekretion dureh eine Behandlung mit Metformin (2 g/Tag). Die Blutzuckerwerte, niichtern und w/~hrend des intra-venSsen G.T.T., wurden nicht beeinflul3t. Auch die K-Werte zeigten trotz eines leichten Abfalls unter der Behandlung keine statistisch signifikante Abweichung yon den Ausgangswerten. Die Insulinspieget, niichtern uad nach Glucose, waren jedoch unter der Behandlung signifikant gesenkt und der Insulin/Glucose-Quotient erniedrigt. Dies 1/il~t auf eine partielle Aufhebung der Insulinresistenz bei iibergewichtigen Patienten schliel3en.

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Section: Discussionmentioning

confidence: 99%