Le carcinome tubulo-mucineux et fusiforme du rein : A propos de deux cas cliniques et une revue de littérature

Mucinous tubular and spindle cell carcinoma: A rare kidney tumour

“…Renal mucinous tubular and spindle cell carcinoma (MTSCC) is an epithelial tumour that accounts for less than 1% of all neoplasms of the kidney [1,2,[5][6]. It affects primarily adult patients aged between 13 and 81 years old (mean age: 58 years old) and shows a female predominance like our patient [1,2,[5][6]. MTSCC is usually incidentally discovered on abdominal imaging as our case [1][2].…”

“…MTSCC express distal nephron markers (EMA, CK19, CK7, E-Cadherin) and proximal tubule markers (RCC Ma, AMACR, CD15) [5][6].…”

“…The main differential diagnosis of MTSCC is papillary renal cell carcinoma (RCC) in its compact variant [1,2,3,[5][6]. Therefore, MTSCC may be distinguishable from papillary RCC by evaluating the presence of a trisomy for chromosomes 7 and 17 [1,2,[3][4][5].…”

“…MTSCC with classic morphology has an excellent prognosis [1,2,5,[6][7][8]. It is a low-grade carcinoma and the treatment consists on partial or radical nephrectomy [1,2,[5][6].…”

“…MTSCC with classic morphology has an excellent prognosis [1,2,5,[6][7][8]. It is a low-grade carcinoma and the treatment consists on partial or radical nephrectomy [1,2,[5][6]. Patients with sarcomatoid change have the worst prognosis and can suffer from recurrence, loco-regional and distant metastasis and death [1,[2][3][4][5][6][7][8].…”