Introduction: Breast cancer is a public health problem because of its frequency and severity. This pathology affects the quality of life of the patient and causes physical, psychological, social and especially sexual sequelae. Materials and Methods: This is a cross-sectional study of 30 patients followed for non-metastatic breast cancer at Monastir Maternity and Neonatal Center. Data collection was conducted using a fact sheet and two internationally validated scales: RSS (Relationship and sexuality) and BESAA (Body-Esteem Scale for Adolescents and Adults). Results: Sexual desire was affected by the disease and its treatments in fourteen patients. The ability to achieve orgasm was reduced in eighteen patients Fourteen patients felt less sexually attractive. Twenty one women reported a decrease in the frequency of sexual intercourse. Four women reported a fear of sex. Dyspareunia and vaginal dryness were present in six women. Women aged 35 to 39 years were significantly more afraid of having sex (p = 0.039) and less sexual frequency (p = 0.003) Hormone therapy was significantly correlated with sexual functioning impairment (p = 0.009) and lower sexual frequency (p = 0.017). Overall, the alteration of the body image was significantly and positively correlated with sexual fear (P = 0.011, r = + 0.46). Altered perception of appearance was significantly and positively correlated with sexual fear (p = 0.008, r = +0.477). The dissatisfaction with weight was significantly and positively correlated with sexual fear (P = 0.011, r = +0.45). Conclusion: Women with breast cancer suffer clear sexual sequelae. These women deserve adequate and collaborative care to ensure a better life.