Le contrôle génétique des maladies infectieuses : des lois de Mendel au séquençage de l’exome

Debré, Patrice; Gall, Jean‐Yves Le; Adolphe,; Marcelli,; Ardaillou, M.M.; Baulieu,; Cabanis,; Cazenave, C.; Denis, Denis; Dreux,; Galibert,; Hauw,; Launois,; Gall, J. Y. Le; Milgrom,; Montagnier,; Netter,; Nezelof,; Nicolas, Jacques; Parodi,; Pessac,; Ronco,; Rosset,; Sraer,; Tiollais,; Thouvenot, Vincent; Dejean-Assemat,; Evain-Brion,; Morel,; Bastide, M.M.; Brice,; Debré,; Delmas,; Delpech,; Douay,; Dussaule,; Friedlander,; Jeanteur,; Bouc, Le; Maquart,; Soubrier,; Stoltz,; Swynghedauw,; Vigneron.,; Caen, M.M.; Chouard,; Rochefort.,; Abel, Laurent; Dessein, Alain; Montagutelli, Xavier; Pïcard, Capucine; Puel, Anne; Alcaïs, Alexandre; Jouanguy, Emmanuelle; Théodorou, Ioannis; Bucheton, Bruno

doi:10.1016/s0001-4079(19)31633-4

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“…The -592A allele of the IL10-592A>C gene is associated with increased viral replication and a significant acceleration of AIDS progression. Carriage frequency of the -592C-allele of the IL10-592A>C gene in healthy people is higher than in patients with tuberculosis [70,71].…”

Section: Genetic Aspectsmentioning

confidence: 85%

Some Immunological and Genetic Aspects of the Development of Traumatic Osteomyelitis: a Review of the Literature

Kholmurodov,

Kobilov,

Karimov

2022

JTO

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This review summarizes features of the pathophysiological course of post-traumatic osteomyelitis. Options for the development of traumatic osteomyelitis in patients with immunological and genetic predispositions are considered. Along with a description of the pathophysiology and conditions for the occurrence of these processes, the features of the pathophysiological course of this disease are described in detail.Molecular genetic studies devoted to the search for an association between polymorphic gene variants and the development of chronic traumatic osteomyelitis are not sufficiently reflected in domestic and foreign literature, which confirms the relevance of this work.Key words: traumatic osteomyelitis, pathophysiology, predisposition, molecular genetic studies

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Section: Genetic Aspectsmentioning

confidence: 85%