Le dernier sursaut des cellules mourantes

Role of Cell Death in Cellular Processes During Odontogenesis

“…Non-apoptotic cells adjacent to those undergoing apoptosis demonstrate altered morphology with their long axes pointing in the opposite direction (Landova Sulcova et al, 2020). Similar folding and shape alterations have been observed in cells located near apoptotic cells during epithelial morphogenesis in Drosophila, where surface bending was induced by localized deformation of the epithelium (Monier et al, 2015), as described in section "Apoptosis in Epithelial Invagination During Early Odontogenesis." In the chameleon, similar apico-basal forces associated with the rearrangement of cytoskeleton were proposed to be the driving mechanism contributing to the final tooth crown shape (Landova Sulcova et al, 2020).…”

“…This localization of apoptotic cells suggests possible involvement of cell death in budding morphogenesis in the epithelium. One possible mechanism for this process may be the induction of epithelial bending through cytoskeletal rearrangement and generation of an apicobasal pulling force, which induces deformation of the surrounding cells and the epithelial surface (Monier et al, 2015). In mouse, phalloidin staining has confirmed uneven distribution of actin filaments in epithelial thickenings during early molar development (Li et al, 2016).…”

“…Moreover, intercellular spaces were found to widen around apoptotic cells, especially in the folding areas (Landova Sulcova et al, 2020), which indicates possible disruptions in cell adhesion molecules and loosening of their connections with neighboring cells. Alteration of protein expression in components of adherens junction molecules such as E-cadherin, α-catenin, and β-catenin are associated with dying cells and to contribute to the surface deformations of epithelial cells in Drosophila (Monier et al, 2015). In chameleons, a similar downregulation was observed in case of Na + /K + -ATPase, acting as a signal transducer (Garcia et al, 2018), during enamel ridge formation (Landova Sulcova et al, 2020), indicating the involvement of apoptotic cells in the modifications of morphogenesis through disruption of cell-cell interactions.…”

“…As cells undergo apoptosis, they become detached from neighboring cells. In fact, cell adhesion changes are associated with the induction of apoptosis, with the expression of membranous complexes becoming altered (Monier et al, 2015). As cells are released from their fixed positions, surrounding cells can actively migrate or be passively translocated to new destinations, which can ultimately affect the final shape of epithelial structures.…”

“…Apoptotic cells can induce the rearrangement of cytoskeleton, causing local deformation of the apical surface of surrounding epithelial cells (Monier et al, 2015). However, it is not known if the apico-basal pulling force, which is generated by the dying cell in the dental epithelium, can be strong enough to induce invagination or cell rearrangement.…”