2017
DOI: 10.11604/pamj.2017.27.37.11663
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Le DRESS syndrome secondaire aux antituberculeux: à propos d’un cas

Abstract: Le syndrome d'hypersensibilité médicamenteuse ou Drug Rash with Eosinophilia and Systemic Symptoms ou DRESS syndrome est une toxidermie grave qui peut mettre en jeu le pronostic vital. Il faut y penser devant toute réaction cutanée après la prise des médicaments. Nous rapportons un cas clinique d'un patient âgé de 45 ans traité pour tuberculose pulmonaire TPM+ présentant un DRESS syndrome induit par les anti-bacillaires.

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Cited by 5 publications
(3 citation statements)
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“…Rifampicin and isoniazid appear to be the most frequently involved molecules, having been identified as the culprit agent in 19 cases (our case 1, and 18 cases in Supporting Information Table S1 and 18 cases (our cases 1 and 2, and 16 cases in Supporting Information Table S1, respectively. This equally applies to tuberculosis patients concomitantly infected with human immunodeficiency virus (HIV) .…”
Section: Discussionmentioning
confidence: 75%
See 1 more Smart Citation
“…Rifampicin and isoniazid appear to be the most frequently involved molecules, having been identified as the culprit agent in 19 cases (our case 1, and 18 cases in Supporting Information Table S1 and 18 cases (our cases 1 and 2, and 16 cases in Supporting Information Table S1, respectively. This equally applies to tuberculosis patients concomitantly infected with human immunodeficiency virus (HIV) .…”
Section: Discussionmentioning
confidence: 75%
“…Ethambutol produced a positive skin test reaction in only three cases (our case 1, and two cases in Supporting Information Table S1), gave a negative skin test result in two patients (Supporting Information Table S1), and was responsible for a doubtful skin test result in our case 2. Ten other patients showed reactions when rechallenged with ethambutol (Supporting Information Table S1). When ethambutol is implicated, it is usually responsible for the drug reaction together with one or more other first‐line antituberculosis drugs.…”
Section: Discussionmentioning
confidence: 99%
“…The index case had cutaneous eruptions, eosinophilia, and systemic manifestations (increased liver enzymes > 2 times greater than normal). There are only a few case reports of DRESS syndrome developing after taking ATT which all improved on cessation of therapy [4]. All ATT drugs have been implicated in causing DRESS, with isoniazid and rifampicin being most common [5].…”
mentioning
confidence: 99%