Le paradoxe cardiovasculaire de la grossesse

St‐Louis, Jean; Brochu, Martin

doi:10.1051/medsci/20072311944

Cited by 8 publications

(3 citation statements)

References 26 publications

(41 reference statements)

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“…Abnormal uterine development, as seen in DES daughters, can compromise pregnancy outcomes (e.g., with a higher incidence of preterm delivery). However, of the numerous disorders of pregnancy, miscarriage, preeclampsia, and intrauterine growth restriction are the most common and are primarily disorders of implantation (abnormal placentation and abnormal decidual-placental interactions) (156, 157). …”

Section: Disruptions Of the Ovarymentioning

confidence: 99%

Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

Crain

Janssen

Edwards

et al. 2008

Fertility and Sterility

397

233

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Objective To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health. Design Publications related to the contribution of EDCs to disorders of the ovary (aneuploidy, polycystic ovary syndrome, and altered cyclicity), uterus (endometriosis, uterine fibroids, fetal growth restriction, and pregnancy loss), breast (breast cancer, reduced duration of lactation), and pubertal timing were identified, reviewed, and summarized at a workshop. Conclusion(s) The data reviewed illustrate that EDCs contribute to numerous human female reproductive disorders and emphasize the sensitivity of early life-stage exposures. Many research gaps are identified that limit full understanding of the contribution of EDCs to female reproductive problems. Moreover, there is an urgent need to reduce the incidence of these reproductive disorders, which can be addressed by correlative studies on early life exposure and adult reproductive dysfunction together with tools to assess the specific exposures and methods to block their effects. This review of the EDC literature as it relates to female health provides an important platform on which women’s health can be improved.

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Section: Disruptions Of the Ovarymentioning

confidence: 99%

Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

Crain

Janssen

Edwards

et al. 2008

Fertility and Sterility

397

233

View full text Add to dashboard Cite

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“…Under normal circumstances, the uterine vasculature undergoes dramatic remodeling in order to accommodate the requisite >10-fold increase in uterine blood flow [1,8,9] that allows for successful pregnancy outcome. In uterine vessels, outward expansive remodeling is seen (increased lumen diameter and unchanged wall thickness) [10,11], which serves to reduce uterine vascular resistance in normal pregnancy [4,12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Pregnancy, Hypertension and Nitric Oxide Inhibition on Rat Uterine Artery Myogenic Reactivity

2010

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Background/Aims: The purpose of this study was to examine the effects of hypertension and nitric oxide (NO) inhibition on myogenic tone in uterine arteries during pregnancy. Methods: Premyometrial radial uterine arteries from nonpregnant and late pregnant Sprague-Dawley rats were evaluated for myogenic reactivity from the following groups: control, hypertensive/NO-inhibited (L-NAME treatment) and normotensive/NO-inhibited (L-NAME plus hydralazine). Results: In both nonpregnant and pregnant animals, L-NAME treatment significantly elevated blood pressures, while the addition of hydralazine made the animals normotensive. In nonpregnant animals, little myogenic tone was seen in controls; tone increased significantly in the L-NAME group, and was attenuated in those treated with L-NAME plus hydralazine. In pregnant animals, controls developed significant tone; this was reduced in the L-NAME group, and returned to control levels in the L-NAME plus hydralazine group. Conclusions: Dimensional measurements showed that arteries from the pregnant hypertensive group did not undergo expansive remodeling, suggesting that tone development is related to phenotypic alterations in vascular smooth muscle and/or altered physical forces secondary to adaptive changes in arterial diameter. These differences implicate pregnancy-specific pathways in the development and inhibition of myogenic tone, and point to potentially opposing roles of NO and hypertension.

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“…2 Pregnancy is a physiological condition of the pregnant woman which can be accompanied with behavior change and modification of maternal organism from conception to childbirth. 1,[3][4][5] Despite in normal condition, pregnancy sometimes involves a vital maternal and fetal prognosis, especially if the woman does not respect some rules of hygiene in case the pregnancy is associated with certain pathologies including hypertension. 4,5 Hypertension is a common situation during pregnancy as it affects 6% to 10% of pregnant women; it is also the first marker of maternal and infant morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Knowledges, Attitudes, and Practices of Health Personnel with Regard to Hypertension During Pregnancy in Hospitals of Bujumbura

Ndirahisha

Nyandwi

Manirakiza

et al. 2021

Indian Journal of Clinical Cardiology

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Objective: To assess knowledges, attitudes, and practices of health personnel in Bujumbura hospitals with regard to hypertension during pregnancy. Methodology: This study has been conducted on health personnel of gynecology and obstetrics department of three national referral hospitals in Bujumbura. It is a descriptive cross-sectional study to assess knowledge, attitudes, and practices. Data were collected by a questionnaire and analyzed by Epi Info 7.2. Results: In a total of ninety-seven health workers participated in our study and 78.3% were paramedics with 53.6% of nurses and 24.7% of midwives. Medical doctors represented 21.6% of the participants. The sex ratio was 1.4 in favor of women. The professional experience was more than 5 years for 64.9% of participants. Concerning knowledge about hypertension; 74.2% of participants correctly defined hypertension during pregnancy. Despite this, only 48.4% respected conditions about its measurement. concerning attitude toword hypertension; 94.8% of participants informed their patients about the risks linked to hypertension in pregnancy before any therapeutic strategy. The antihypertensive drugs contraindicated during pregnancy were known by 54.6% of participants. To prevent preeclampsia, low doses of aspirin and calcium were prescribed by 42.2% of participants. Conclusion: Hypertension during pregnancy is a worrying situation for health personnel, which still has many theoretical and practical gaps.

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Le paradoxe cardiovasculaire de la grossesse

Cited by 8 publications

References 26 publications

Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

Effects of Pregnancy, Hypertension and Nitric Oxide Inhibition on Rat Uterine Artery Myogenic Reactivity

Assessment of Knowledges, Attitudes, and Practices of Health Personnel with Regard to Hypertension During Pregnancy in Hospitals of Bujumbura

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