Le propacétamol: des données fondamentales à l'utilisation clinique

Exploring acetaminophen prodrugs and hybrids: a review

“…71 As a result, its onset of analgesia is more rapid than that from APAP ordered orally or rectally. [72][73][74] Thus, propacetamol cannot be administered orally due to its greater water solubility. Interestingly, 4-AAC-APAP derivatives were proposed by Kovach et al in 1981 as potentially useful prodrugs.…”

Prodrug ionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form

“…However, only a few prodrug salts have been reported, including Na + or K + salts of acetaminophen derivatized with phosphoric acid moieties 23d and Cl À salts derived from the attachment of an amine moiety, e.g., propacetamol HCl. 25 All of these salts are crystalline solids.…”