Le rétinoblastome : état des lieux au Mali et programme d’aide au diagnostic précoce, aux traitements et à la réhabilitation

Traoré, Fousseyni; Togo, Boubacar; Sylla, Fatoumata; Cheick, Traoré B.; Diakite, A.; Dicko-Traoré, F.; Sylla, Mariam; Sidibé, Toumani; Doz, François; Harif, Mhamed; Bey, P.; Desjardins, Laurence

doi:10.1684/bdc.2013.1703

Cited by 25 publications

(14 citation statements)

References 5 publications

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“…24 Retinoblastoma-specific twinning programmes include partnerships between St. Jude’s Children’s Research Hospital (USA) and the Middle-East, 25 Central America 26 and Mexico, 22 and between the Institut Curie and a centre in Bamako, Mali. 27 The Central American Association of Paediatric Hematology Oncology (AHOPCA) created a cooperative group and implemented multicentre protocols for retinoblastoma treatment, 26,28,29 a major achievement, not yet paralleled in developed countries. The AHOPCA funding is now 90% local.…”

Section: Epidemiologymentioning

confidence: 99%

Retinoblastoma

Dimaras

Corson

Cobrinik

et al. 2015

Nat Rev Dis Primers

466

390

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Retinoblastoma is a rare cancer of the infant retina, which forms when both RB1 alleles mutate in a susceptible retinal cell, likely a cone photoreceptor precursor. Loss of the tumour suppressor functions of the retinoblastoma protein, pRB, leads to uncontrolled cell division and recurrent genomic changes during tumour progression. Although pRB is expressed in virtually all tissues, cone precursors have biochemical and molecular features that may sensitize to RB1 loss to enable tumourigenesis. Retinoblastoma is diagnosed in ~8,000 children each year worldwide. Patient survival is >95% in high-income countries, but <30% globally. However, outcomes are improving through increasing awareness for earlier diagnosis, new guidelines and sharing of expertise. Intra-arterial and intravitreal chemotherapy have emerged as promising methods to salvage eyes. Ongoing international collaborations will replace the multiple different classifications of eye involvement with standardized definitions to consistently assess eligibility, efficacy and safety of treatment options. Life-long follow-up is warranted since survivors of heritable retinoblastoma are at risk for developing second cancers. Defining the molecular consequences of RB1 loss in diverse tissues may open new avenues for treatment and prevention of retinoblastoma as well as second cancers in patients with germline RB1 mutations.

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Section: Epidemiologymentioning

confidence: 99%

Retinoblastoma

Dimaras

Corson

Cobrinik

et al. 2015

Nat Rev Dis Primers

466

390

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“…Traditional healers are far from being the only ones to be responsible for this delay in diagnosis. 40 In sub-Saharan Africa, a high proportion of parents have minimal education, 14 and the lack of awareness of retinoblastoma remains predominant in all communities (public and health care professionals). 5 , 13 , 14 , 28 However, to our knowledge, the relationship between the educational level of parents and the lag time of diagnosis and management of retinoblastoma has not been proven.…”

Section: Discussionmentioning

confidence: 99%

“…40 In sub-Saharan Africa, a high proportion of parents have minimal education, 14 and the lack of awareness of retinoblastoma remains predominant in all communities (public and health care professionals). 5 , 13 , 14 , 28 However, to our knowledge, the relationship between the educational level of parents and the lag time of diagnosis and management of retinoblastoma has not been proven. In our study, the diagnosis delay is longer for divorced families than married partners, which we attribute to the number of children and increased responsibility of the mother and in most instances of the grandmother—but the difference is not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that the delayed diagnosis of retinoblastoma is associated with extraocular forms of the disease and reduced rates of patient survival. 4 , 18 - 20 Several studies have previously described the access to diagnosis and care of retinoblastoma diagnosis and management, 14 , 21 - 24 but few studies have evaluated the factors contributing to delayed diagnosis, particularly in French-speaking sub-Saharan African countries.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Retinoblastoma in Sub-Saharan Africa: Case Studies of the Republic of Côte d’Ivoire and the Democratic Republic of the Congo

Lukamba

Kabesha

Budiongo

et al. 2018

JGO

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PurposeIn most low-income countries, the diagnosis of retinoblastoma is delayed, resulting in a severe prognosis. The objectives of this study were to describe the access to diagnosis and care of children diagnosed with retinoblastoma and the challenges in two sub-Saharan African countries: the Republic of Côte d’Ivoire and the Democratic Republic of the Congo.Patients and MethodsA descriptive cross-sectional study was conducted. Data were collected from the medical records of patients admitted during the period of January 1, 2013 to December 31, 2014. Data were entered and analyzed using Epi Info7.1 software and SAS 9.3.ResultsOne hundred sixteen cases of retinoblastoma were collected, including 60 boys and 56 girls. The median diagnosis age was 3 years for both countries. Ninety-eight patients (84%) had unilateral retinoblastoma. Most of the patients presented with advanced disease (76% had extraocular retinoblastoma). Median time between initial symptoms and diagnosis was 8.5 months (range, 0.4 to 116.7 months). Median time between diagnosis and treatment initiation was 31 days (range, 0 to 751 days). The median cost for the treatment of the disease was estimated at $1,954 per patient.ConclusionLate diagnosis of retinoblastoma, with extraocular disease, occurs frequently in both African countries. It is associated with delay in initiating treatment, and the cost of the treatment remains unaffordable for most of the families. Support groups for parents of affected children and the support of the Franco-African Pediatric Oncology Group remain important in improving early diagnosis and providing treatment in sub-Saharan African countries.

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“…10,11 There are many examples of successful collaborative programs for retinoblastoma between HICs and low-income countries. 12,13 However, there is more limited information about partnerships between HIC and upper–middle-income countries—even less so in the field of retinoblastoma, for which the priorities may be different. 8 …”

mentioning

confidence: 99%