Le xanthogranulome de l’adulte

Malbos, S; Guilhou, Jean‐Jacques; Meynadier, J; Barnéon, G.; Baldet, Piérre

doi:10.1159/000250777

Cited by 19 publications

(1 citation statement)

References 2 publications

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“…The male-to-fetnale ratio is 4:1. The lesions usually involute spontaneously, but they may persist for several years {10, 13,17,18). Microscopically, Touton giant cells are prominent in this entity.…”

Section: Discussionmentioning

confidence: 99%

Unusual expression of S‐100 protein in histiocytic neoplasms

Tomaszewski

Lupton

1998

J Cutan Pathol

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Twenty-nine cases of histiocytic neoplasms, some resembling juvenile xanthogranuloma (JXG) and others resembling reticulohistiocytoma (RH), were evaluated. Immunohistochemical stains were performed. In this series, seven cases were identified that expressed S-100 protein positive cells. The S-100 positive cells were predominantly large mononuclear and multinucleated histiocytes with eosinophilic cytoplasm, but also in some cases xanthomatous cells and Touton giant cells. These cells also expressed a positive reaction for vimentin, KP-1, and Factor XIIIa. There was no reactivity observed for monoclonal antibody 010(CD1a). A positive reaction for S-100 protein is conventionally accepted as a useful differentiating feature between histiocytosis X and non-X histiocytosis such as JXG and RH. The conflicting results of the immunohistochemical stains in the lesions we studied could be potential pitfalls in diagnosing histiocytic neoplasms.

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Section: Discussionmentioning

confidence: 99%