Le xénon ne réduit pas les besoins d’opioïdes en chirurgie orthopédique

Luginbühl, Martin; Petersen-Felix, Steen; Zbinden, A. M.; Schnider, Thomas W.

doi:10.1007/bf03018578

Cited by 16 publications

(10 citation statements)

References 34 publications

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“…Of these, we selected 225 for full‐text review, of which 188 papers were excluded because they did not meet our eligibility criteria. After this process we identified a further 15 papers, reporting on 12 studies , which also required exclusion for not meeting these criteria. Of these 12 studies, six did not include an intervention or comparator relevant to this review , in five studies the depth of anaesthesia differed between study arms [ and two papers reported on the ENIGMA‐2 study , which did not measure AAGA.…”

Section: Resultsmentioning

confidence: 99%

Nitrous oxide‐based vs. nitrous oxide‐free general anaesthesia and accidental awareness in surgical patients: an abridged Cochrane systematic review

et al. 2017

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Summary Accidental awareness during general anaesthesia can arise from a failure to deliver sufficient anaesthetic agent, or from a patient's resistance to an expected sufficient dose of such an agent. Awareness is ‘explicit’ if the patient is subsequently able to recall the event. We conducted a systematic review into the effect of nitrous oxide used as part of a general anaesthetic on the risk of accidental awareness in people over the age of five years undergoing general anaesthesia for surgery. We included 15 randomised controlled trials, 14 of which, representing a total of 3439 participants, were included in our primary analysis of the frequency of accidental awareness events. The awareness incidence rate was rare within these studies, and all were considered underpowered with respect to this outcome. The risk of bias across all studies was judged to be high, and 76% of studies failed adequately to conceal participant allocation. We considered the available evidence to be of very poor quality. There were a total of three accidental awareness events reported in two studies, one of which reported that the awareness was the result of a kink in a propofol intravenous line. There were insufficient data to conduct a meta‐ or sub‐group analysis and there was insufficient evidence to draw outcome‐related conclusions. We can, however, recommend that future studies focus on potentially high‐risk groups such as obstetric or cardiac surgery patients, or those receiving neuromuscular blocking drugs or total intravenous anaesthesia.

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Section: Resultsmentioning

confidence: 99%

Nitrous oxide‐based vs. nitrous oxide‐free general anaesthesia and accidental awareness in surgical patients: an abridged Cochrane systematic review

et al. 2017

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“…31 In the first study 31 (data set I, 'I' for infusion data), 30 patients undergoing orthopaedic surgery were randomly allocated to anaesthesia with 70 vol.% of xenon or 70 vol.% of nitrous oxide plus 2 vol.% of desflurane. Alfentanil was administered by TCI (Stanpump programme, S.L.…”

Section: Methodsmentioning

confidence: 99%

“…To carry out the study where the data of alfentanil infusions were taken 31 Drä ger Medical GmbH, Lü beck, Germany provided a Cicero Anaesthesia Workstation adapted for the administration of xenon. The xenon was generously provided by Messer Griessheim GmbH, Krefeld, Germany.…”

Section: Acknowledgementmentioning

confidence: 99%

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Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems

Sigmond

Baechtold

Schumacher

et al. 2013

British Journal of Anaesthesia

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“…Among 142 surgical patients xenon anesthesia was well tolerated except for more nausea and vomiting compared to those randomized to propofol (30). Several other studies in surgical patients reported xenon was well tolerated as an anesthetic (31)(32)(33)(34). In a pilot study of critical care sedation for 8 hours, 21 patients randomized to either propofol or inhaled xenon (9-62 %) had comparable sedation.…”

Section: Introductionmentioning

confidence: 91%

Xenon as a Neuroprotectant in Traumatic Brain Injury

Saukkonen¹

2012

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE March 2012 REPORT TYPE Final Report SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES14. ABSTRACT-The purpose of this study was to determine if xenon has a neuroprotectant effect in an vivo animal model of TBI. The Specific Aims were to determine the effect of inhaled xenon on brain histopathology, behavior, in short-and long-term fluid percussion (FP) and controlled cortical impact (CCI) rat models of TBI compared to controls. A unique xenon-recirculation delivery device in which the concentration of xenon and oxygen are reproducibly and accurately controlled and conserved was developed and manufactured. Outcome measures planned included histology and neurobehavioral measures. Data from initial experiments reported in 2010 using the CCI model and 50% xenon administration could not be utilized, as we discovered that although IACUC and VA Research Approvals were in place, ACURO approval was not in place. ACURO application documents were submitted again directly. Furthermore, the rat line that was utilized for the TBI model was discontinued by the supplier, necessitating a change to a different rat line. Extensive administrative and financial revisions to the SOW and budget subsequently ensued to try to feasibly achieve the revised scientific ends of the project. Administrative and financial issues between DoD and the primary recipient organization were not resolved before the final expiry of the project and before any studies could proceed with appropriate approvals in place.

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Le xénon ne réduit pas les besoins d’opioïdes en chirurgie orthopédique

Abstract: P Pu ur rp po os se e: : Is to test the hypothesis that 70% xenon has a relevant opioid sparing effect compared to a minimum alveolar concentration (MAC)-equivalent combination of N 2 O and desflurane.

Cited by 16 publications

References 34 publications

Nitrous oxide‐based vs. nitrous oxide‐free general anaesthesia and accidental awareness in surgical patients: an abridged Cochrane systematic review

Nitrous oxide‐based vs. nitrous oxide‐free general anaesthesia and accidental awareness in surgical patients: an abridged Cochrane systematic review

Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems

Xenon as a Neuroprotectant in Traumatic Brain Injury

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