Lead and Arsenic Levels in Women with Different Body Mass Composition

Ronco, Ana María; Gutiérrez, Yareni; Gras, N.; Muñoz, Lorena; Salazar, Gabriela; Llanos, Miguel

doi:10.1007/s12011-009-8546-z

Cited by 29 publications

(23 citation statements)

References 26 publications

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“…In another study, Ronco and colleagues also found no significant correlation between blood lead level and both BMI and body fat percentage. In addition, this study also could not reveal the role of BMI or body composition in the regulation of lead toxicity (Ronco et al 2010). Our finding, however, was in contrast with a previous study by Rustanti and Mahawati involving public transportation drivers where a significant negative correlation was indicated between blood lead level and BMI (r=-0.38; p<0.05) (Rustanti & Mahawati 2011).…”

Section: Resultscontrasting

confidence: 99%

Association between Blood Lead, Nutritional Status, and Risk Factors of Hypertension and Diabetes Mellitus: A Study in Female Traffic Police Officers in Yogyakarta

et al. 2018

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The research aimed to investigate the association of nutritional status, blood lead level, and risk factors of hypertension and diabetes mellitus in female traffic police officers routinely exposed to lead in Yogyakarta, Indonesia. Fifty-four female traffic police officers aged 20-50 year old participated in this cross-sectional study. As risk factors of diabetes and hypertension, Body Mass Index (BMI) was calculated from height and weight data while percentage of body fat (%BF) was measured using Bioelectrical Impedance Analysis (BIA). Energy intake (EI) was assessed using 1x24-hour dietary recall. Atomic Absorption Spectrophotometer (AAS) method was conducted to measure blood lead (Pb-S). Blood pressure (BP) was measured using mercury sphygmomanometer while blood glucose (Glu) was measured in laboratory. Pearson's and Spearman Rank correlation test were performed for statistical analysis. We demonstrated that Pb-S was positively correlated with both systolic and diastolic BP but not with BMI, %BF, and Glu. Meanwhile, there was a correlation between Glu and either BMI or %BF but not EI. Therefore, our study indicates that exposure to lead is correlated with hypertension while nutritional status is more correlated with diabetes mellitus.

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Section: Resultscontrasting

confidence: 99%

Association between Blood Lead, Nutritional Status, and Risk Factors of Hypertension and Diabetes Mellitus: A Study in Female Traffic Police Officers in Yogyakarta

et al. 2018

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“…Human studies show conflicting evidence with Pb measured in teeth positively correlating with BMI at age 7, while Pb levels in patella and tibia of children the same age did not correlate with BMI, and cross-sectional studies of blood lead level found no association with obesity in 11 year old children or adult women [10], [38]–[40]. In contrast, Pb had a negative association with BMI and waist circumference in the NHANES 1999–2000 cohort [11].…”

Section: Discussionmentioning

confidence: 94%

Perinatal Lead (Pb) Exposure Results in Sex-Specific Effects on Food Intake, Fat, Weight, and Insulin Response across the Murine Life-Course

et al. 2014

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Developmental lead (Pb) exposure has been associated with lower body weight in human infants and late onset obesity in mice. We determined the association of perinatal Pb exposure in mice with changes in obesity-related phenotypes into adulthood. Mice underwent exposure via maternal drinking water supplemented with 0 (control), 2.1 (low), 16 (medium), or 32 (high) ppm Pb-acetate two weeks prior to mating through lactation. Offspring were phenotyped at ages 3, 6, and 9 months for energy expenditure, spontaneous activity, food intake, body weight, body composition, and at age 10 months for glucose tolerance. Data analyses were stratified by sex and adjusted for litter effects. Exposed females and males exhibited increased energy expenditure as compared to controls (p<0.0001 for both). In females, horizontal activity differed significantly from controls (p = 0.02) over the life-course. Overall, food intake increased in exposed females and males (p<0.0008 and p<0.0001, respectively) with significant linear trends at 9 months in females (p = 0.01) and 6 months in males (p<0.01). Body weight was significantly increased in males at the medium and high exposures (p = 0.001 and p = 0.006). Total body fat differed among exposed females and males (p<0.0001 and p<0.0001, respectively). Insulin response was significantly increased in medium exposure males (p<0.05). Perinatal Pb exposure at blood lead levels between 4.1 µg/dL and 32 µg/dL is associated with increased food intake, body weight, total body fat, energy expenditure, activity, and insulin response in mice. Physiological effects of developmental Pb exposure persist and vary according to sex and age.

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“…Whereas Both Miguel A. Padilla et al and Franco Scinicariello et al reported that BLL associated with lower body weight in adults based on data from NHANES [1, 21]. In another study, no association was found between BLL and BMI in adults [22]. The conflicting results may be due to ethnic variations as well as different BLL of the study population.…”

Section: Discussionmentioning

confidence: 97%

Lead Exposure Induces Weight Gain in Adult Rats, Accompanied by DNA Hypermethylation

et al. 2017

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ObjectivePrevious studies have revealed the association of lead (Pb) exposure with obesity. DNA methylation alteration has been suggested to be one of the regulatory mechanisms of obesity. We aimed to explore whether Pb exposure is related with weight gain and DNA methylation alteration.MethodsMale adult 8 week Wistar rats were divided into 5 groups: the normal chow diet (NCD); the NCD+0.05%Pb; the NCD+0.15%Pb; the NCD+0.45%Pb and the high fat diet. Rats were exposed to different dosages of Pb through drinking water for 21 weeks. Body weight, fasted blood glucose level, fasted insulin level, homeostasis assessment of insulin resistance (HOMA-IR) index and lipid profile were detected. Intra-peritoneal glucose tolerance test (IPGTT) was constructed to evaluate the glucose tolerance. Lipid accumulation of liver was detected and liver DNA underwent whole genome bisulfite sequencing.ResultsThe NCD+0.05%Pb group had significantly greater weight, HOMA-IR and triglycerides, and lower glucose intolerance than the NCD group (P <0.05). This group also showed hepatic lipid accumulation. These metabolic changes were not observed in the other two Pb dosage groups. Furthermore, DNA hypermethylation extended along pathways related to glucose and lipid metabolism in NCD+0.05%Pb group.ConclusionPb exposure resulted in dose-specific weight gain in adult Wistar rats, accompanied by alteration of DNA methylation.

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Lead and Arsenic Levels in Women with Different Body Mass Composition

Cited by 29 publications

References 26 publications

Association between Blood Lead, Nutritional Status, and Risk Factors of Hypertension and Diabetes Mellitus: A Study in Female Traffic Police Officers in Yogyakarta

Association between Blood Lead, Nutritional Status, and Risk Factors of Hypertension and Diabetes Mellitus: A Study in Female Traffic Police Officers in Yogyakarta

Perinatal Lead (Pb) Exposure Results in Sex-Specific Effects on Food Intake, Fat, Weight, and Insulin Response across the Murine Life-Course

Lead Exposure Induces Weight Gain in Adult Rats, Accompanied by DNA Hypermethylation

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