Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol

Abstract

Lead and cadmium are known as environmental pollutants extensively found in food and water that induce hazards to animals' and people's health. Sesamol is a dietary antioxidant that is found in some plants. Epididymis is known to play an important role in the maturation and storage of the sperm. The spleen is an important organ involved in the immune response.The present study aims to analyze the oxidative stress in spleen and epididymis. Therefore, Lead (LN) (90 mg/kg bw per day, 1/25 LD50), Cadmium (CdCl2) (3 mg/kg bw per day, 1/25 LD50), and sesamol (50 mg/kg bw per day) were given to rats by gavage for 28 days. Antioxidant enzyme activities in epididymis and spleen tissues [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S transferase], malondialdehyde (MDA) were investigated at the end of 28 days comparatively with the control group. It is revealed that there is a significant decline in the antioxidant enzymes and increase in MDA levels in the spleen and epididymis tissues of the lead and cadmium treated rats compared to the control group. A small increase in these parameters was also observed in the sesamol treated groups.

Bioremoval of Lead from Polluted Waters Using the Fungus Talaromyces stipitatus and Its Impact on Male Albino Rats

“…12c, d & Table 5). These results are attributed to oxidative stress and lipid peroxidation, causing serious harm to the epididymis after Pb intoxication by increasing lipid peroxidation damage in the epididymis and causing differences in antioxidant levels in the epididymal sperm and the male reproductive system ( Latchoumycandane et al, 2003;Apaydin et al, 2021). In treatment group, macroscopic examination of the epididymis showed a significant increase in the diameter of epididymal ducts containing numerous mature spermatozoa inside epididymal ducts (Figs.12e, f & Table 5).…”

Protective Role of Ferulic Acid on Testis-Histoarchitecture and Oxidative Damages Induced by Dimethoate in Rats

“…Oxidative stress is a result of out of balance between reactive oxygen species and antioxidant enzyme defense system, and this balance benefits ROS. This oxidative stress effects a number of cellular functions and caused to various pathological situations in which ROS overwhelm anti-oxidative conservation of the organism, leading to oxidative ruin of the mentioned biological macromolecules, tissue damage, and necrosis as the foundation [20,21]. In this study we aim examine oxidative stress and pathological changes of the testis of rats after 4-week-subacute exposure to dimethoate and to assess the protective potential of ferulic acid.…”