Lead and δ-aminolevulinic acid concentrations in human parotid saliva

Digregorio, G. John; Ferko, Alexander; Sample, Richard G.; Bobyock, Emil; McMichael, Robert; Chernick, Warren S.

doi:10.1016/0041-008x(74)90028-3

Cited by 24 publications

(15 citation statements)

References 9 publications

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“…14 Similar findings have been reported in other non-occupational populations [52][53][54][55] and in more recent epidemiological community studies in Thailand and Mexico. 56 57 Moreover, blood contamination of saliva during sampling can spuriously raise salivary lead levels because the lead level in whole blood is 2-6 times higher than that in saliva.…”

Section: Salivary Leadsupporting

confidence: 77%

The use of salivary biomarkers in occupational and environmental medicine

Koh

2007

Occup Environ Med

123

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Section: Salivary Leadsupporting

confidence: 77%

The use of salivary biomarkers in occupational and environmental medicine

Koh

2007

Occup Environ Med

123

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“…However, the correlation was weak. This is in agreement with the findings of DiGregorio et al . and Nriagu et al ,.…”

Section: Discussionsupporting

confidence: 94%

“…who also investigated children exposed to lead in a contaminated area. DiGregorio et al . also reported a similar ratio between PbS and PbB in normal adults.…”

Section: Discussionmentioning

confidence: 61%

Salivary lead in relation to caries, salivary factors and cariogenic bacteria in children

Youravong

Teanpaisan

Chongsuvivatwong

2013

International Dental Journal

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“…Parotid saliva secretion is an excretory route for lead (DiGregorio et al 1974), most likely by a passive diffusion process. Salivary lead concentration is correlated with whole blood lead concentration but is much lower in magnitude (Mobarak and P'an 1984;P'an 1981), has a half-life less than 25% as long as whole blood lead, and falls more rapidly than does blood lead concentration after exposure stops (Brodeur et al 1983).…”

Section: Discussionmentioning

confidence: 99%

Blood lead level and dental caries in school-age children.

Gemmel

Tavares

Alperin

et al. 2002

Environ Health Perspect

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The association between blood lead level and dental caries was evaluated in cross-sectional analyses of baseline data for 543 children 6-10 years old screened for enrollment in the Children's Amalgam Trial, a study designed to assess potential health effects of mercury in silver fillings. Approximately half of the children were recruited from an urban setting (Boston/Cambridge, MA, USA) and approximately half from a rural setting (Farmington, ME, USA). Mean blood lead level was significantly greater among the urban subgroup, as was the mean number of carious tooth surfaces. Blood lead level was positively associated with number of caries among urban children, even with adjustment for demographic and maternal factors and child dental practices. This association was stronger in primary than in permanent dentition and stronger for occlusal, lingual, and buccal tooth surfaces than for mesial or distal surfaces. In general, blood lead was not associated with caries in the rural subgroup. The difference between the strength of the associations in the urban and rural settings might reflect the presence of residual confounding in the former setting, the presence of greater variability in the latter setting in terms of important caries risk factors (e.g., fluoride exposure), or greater exposure misclassification in the rural setting. These findings add to the evidence supporting a weak association between children's lead exposure and caries prevalence. A biologic mechanism for lead cariogenicity has not been identified, however. Our data are also consistent with residual confounding by factors associated with both elevated lead exposure and dental caries.

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Lead and δ-aminolevulinic acid concentrations in human parotid saliva

Cited by 24 publications

References 9 publications

The use of salivary biomarkers in occupational and environmental medicine

The use of salivary biomarkers in occupational and environmental medicine

Salivary lead in relation to caries, salivary factors and cariogenic bacteria in children

Blood lead level and dental caries in school-age children.

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