Lead, Blood Pressure, and Cardiovascular Disease in Men

Schwartz, Joel

doi:10.1080/00039896.1995.9955010

Cited by 150 publications

(109 citation statements)

References 38 publications

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“…This may possibly have affected the estimate of the combined association size. A meta-analysis performed by Schwartz J et al 70 in 1995 included 15 studies and showed that a doubling of the blood lead concentration was associated with a significant increase of 1.25 mm Hg in systolic blood pressure, which was 0.25 mm Hg higher than in the present analysis.…”

Section: Discussioncontrasting

confidence: 60%

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

et al. 2002

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Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58 518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and

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Section: Discussioncontrasting

confidence: 60%

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

et al. 2002

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“…Increased blood pressure is probably the most sensitive adverse health effect observed in lead poisoning. Several epidemiological studies have found a significant association between increased blood pressure and body lead burden (31,32). A slight decrease in calcium level was observed, indicating the effect of lead on vitamin D and calcium metabolism (33).…”

Section: Resultsmentioning

confidence: 96%

Lead Toxicity in a Family as a Result of Occupational Exposure

Raviraja¹,

Babu²,

Bijoor³

et al. 2008

Archives of Industrial Hygiene and Toxicology

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This article describes an entire family manufacturing lead acid batteries who all suffered from lead poisoning. The family of five lived in a house, part of which had been used for various stages of battery production for 14 years. Open space was used for drying batteries. They all drank water from a well located on the premises. Evaluation of biomarkers of lead exposure and/or effect revealed alarming blood lead levels [(3.92±0.94) , while blood pressure was high in the head of the family and his wife and normal in children. Lead concentration in well water was estimated to 180 µg L -1 . The family was referred to the National Referral Centre for Lead Poisoning in India, were they were received treatment and were informed about the hazards of lead poisoning. A follow up three months later showed a slight decrease in blood lead levels and a significant increase in haemoglobin. These findings can be attributed to behavioural changes adopted by the family, even though they continued producing lead batteries.

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“…Population research on the cardiovascular effects of Pb has focused largely on the association with blood pressure and hypertension. Meta-analyses of more than 60 researches show strong relationship between systolic and diastolic blood pressure and elevated blood Pb level [22][23][24]. High blood Pb level also correlates cardiovascular mortality and prevalence of peripheral arterial diseases [25][26].…”

Section: Introductionmentioning

confidence: 99%

Effects of age, gender, BMI, settlement and smoking on lead and cadmium accumulation in heart tissue

Dip¹,

İritaş²,

Mergen³

et al. 2017

Med-Science

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Cadmium (Cd) and lead (Pb) are well-known risk factors for peripheral arterial and some other cardiovascular diseases. The aim of the study was to determine the level of both toxic metals, in the human heart tissue and compare the accumulation to their age, gender, body mass index, living environment and smoking habit. Heart tissues of the 112 autopsy cases, representing a sample set of population living in capital city of Turkey: Ankara Province (both in city center and suburban), were collected from Turkey Ministry of Justice, Council of Forensic Medicine in Ankara Branch. Lead and cadmium analysis was carried out by Graphite Furnace Atomic Spectrometry technique. Cd/Pb results and individuals' information were assessed by SPSS statistically. Average value of Pb was found as 1374.99±237.01ppb and Cd was found as 287.54±66.43ppb in all heart tissue samples. Consideration of metal levels in autopsy heart tissues by age, statistically significant positive correlation in Cd was observed (p<0.05). There was no correlation found between metal levels with gender and BMI values. Both Pb and Cd levels of the samples who lived in urban was significantly greater than in suburban areas (p<0.05). Significant increase Cd level were observed in smokers' heart tissues (p<0.05), however, contrary to expectations, Pb has no statistically significant result.

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Lead, Blood Pressure, and Cardiovascular Disease in Men

Cited by 150 publications

References 38 publications

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

Lead Toxicity in a Family as a Result of Occupational Exposure

Effects of age, gender, BMI, settlement and smoking on lead and cadmium accumulation in heart tissue

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