Lead-induced alterations in rat kidneys and testes<i>in vivo</i>

Massányi, Peter; Lukáč, Norbert; Makarevich, Alexander V.; Chrenek, Peter; Forgács, Zsolt; Zakrzewski, Marian; Stawarz, Robert; Toman, R.; Lazor, Peter; Flešárová, Slávka

doi:10.1080/10934520701244474

Cited by 25 publications

(3 citation statements)

References 25 publications

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“…Similar results were found byCupertino et al (2017) [6] in rats exposed to different concentrations of Cd for 7 days, and by [57] using Pb for 48 hours. The exposure time may have been insu cient for the appearance of alterations, sinceSouza et al (2016) [58] reported changes in these parameters in animals exposed to As 5+ and As 3+ for 56 days Saxena et al (1990) [45].…”

supporting

confidence: 89%

Comparative Toxicology of Heavy Metals Arsenate, Arsenite, Cadmium, Chrome Vi, Lead, and Nickel in the Testes of Adult Swiss Mice After Acute Exposure

Lozi

Dias

Silva

et al. 2022

Preprint

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Heavy metals are found naturally in the environment in small concentrations and the increase in their concentration occurs due to anthropogenic activities. Human exposure to heavy metals can induce various testicular damage. This study aimed to evaluate the action of the arsenate (As + 5), arsenite (As + 3), cadmium (Cd), lead (Pb), chromium VI (Cr VI), and nickel (Ni) in the testicles of adult Swiss mice and establish an order of toxicity among these metals. Forty-two animals were randomly distributed into 7 experimental groups (n = 6). The control group received a saline solution and the other groups received 1.5 mg/kg of the heavy metal as follows: group 2 – As + 5, group 3 - As + 3, group 4 - Cd, group 5 - Pb, group 6 - Cr VI and group 7 - Ni. The administration was performed intraperitoneally in a single dose and the animals were euthanized seven days after exposure. Acute exposure to heavy metals induced functional, cellular, pathological, and oxidative stress alterations. The order of toxicity among the tested metals established by comparative damage analysis follows Ni > Cd > Cr VI = Pb > As + 3 > As + 5. In groups with higher toxicity, such as nickel and cadmium were observed functional changes, alterations in the testicular microstructure, and cell death. Based on our results, we can point out that the heavy metals tested can be harmful to male reproductive health in low doses and for a short period of exposure. Care must be greater taking into account the damage order defined in this work.

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confidence: 89%

Comparative Toxicology of Heavy Metals Arsenate, Arsenite, Cadmium, Chrome Vi, Lead, and Nickel in the Testes of Adult Swiss Mice After Acute Exposure

Lozi

Dias

Silva

et al. 2022

Preprint

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“…Lead toxicity may cause loss of vision by affecting eye retina [17]. It may cause circulatory problems, and it may cause excretory problems by affecting the kidney [29]. Lead also may cause acute brain herniation [4,5].…”

Section: Discussionmentioning

confidence: 99%

Di-Mercapto Succinic Acid (DMSA) and vitamin C chelating potency in lead intoxication, regarding oxidative stress and apoptotic related proteins in rabbits

Raafat¹,

Elbarbary

Touson

et al. 2011

Journal of Genetic Engineering and Biotechnology

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Free radicals interact with other molecules within cells. This can cause oxidative damage to proteins, membranes and genes. Oxidative damage has been implicated in the cause of many diseases such as cancer and Alzheimer's and has an impact on the body's aging process. External factors such as pollution, sunlight and smoking also trigger the production of free radicals and the process of programmed cell death (PCD) that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. The study was conducted to 42 male Orycytolagus Cuniculus rabbits. These animals were subdivided into seven groups approaching the comparison between treatment with vitamin C and Di-Mercapto Succinic Acid (DMSA) including positive and negative control groups. Lead ions concentration in blood, liver, kidney and brain were measured before and after treatments application. Apoptotic related proteins P53 and Bcl2 were estimated beside histological studies of tissues. Results revealed that it is more saving to use vitamin C as a lead chelator than DMSA. It is also can be stated that severe lead toxicity can be carcinogenic by increasing the oxidative stress * Corresponding author. Permanent address:

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“…The lead used in this study was Lead (II) acetate trihydrate (Millipore Merck), at a dose of 50 mg/kg bw (Massanyi et al, 2007). Lead acetate was dissolved in distilled water for oral application (Septiani et al, 2022).…”

Section: Lead Acetate Dosementioning

confidence: 99%

White guava (Psidium guajava L.) fruit juice ameliorated the number of spermatogenic cells in rats (Rattus Novergicus) exposed to lead acetate

Muhammad Faizal Adiutomo,

Suzanita Utama,

Herry Agoes Hermadi

et al. 2024

Ovz

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This study aims to determine the effect of oral administration of white guava fruit juice (Psidium guajava L.) on the spermatogenic cells of rats (Rattus norvegicus) exposed orally to lead acetate. Twenty-five male rats (Rattus norvegicus) of the Wistar strain were randomly divided into five groups. Placebo group rats (P0) were given 0.5 mL distilled water twice every day orally at four-hour intervals. Groups T0, T1, T2, and T3 were given lead acetate 50 mg/kg bw orally, then respectively given distilled water, 100, 50 and 25% (v/v) white guava (Psidium guajava L.) fruit juice orally four hours later for 14 days. On day-15, the rats were sacrificed and their testicles were taken for histological preparations. Data were analyzed using Analysis of Variance followed by Duncan's Multiple Range Test. The results showed that the number of spermatogonia, spermatocytes and spermatids cells of rats in T0 group was lower (p <0.05) than in P0 group. Higher spermatogonia, spermatocytes and spermatids cells (p <0.05) were found in the T1 group compared to the T0 group. However, the number of spermatogonia and spermatocytes in the T1 group was still lower than in the P0 group. The number of spermatids in the T3 group was almost the same (p >0.05) as in the P0 group. This study found that white guava pure juice without dilution was the best for maintaining the number of spermatids, but was unable to restore the number of spermatogonia and spermatocyte cells in rats exposed to lead acetate.

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Lead-induced alterations in rat kidneys and testesin vivo

Cited by 25 publications

References 25 publications

Comparative Toxicology of Heavy Metals Arsenate, Arsenite, Cadmium, Chrome Vi, Lead, and Nickel in the Testes of Adult Swiss Mice After Acute Exposure

Comparative Toxicology of Heavy Metals Arsenate, Arsenite, Cadmium, Chrome Vi, Lead, and Nickel in the Testes of Adult Swiss Mice After Acute Exposure

Di-Mercapto Succinic Acid (DMSA) and vitamin C chelating potency in lead intoxication, regarding oxidative stress and apoptotic related proteins in rabbits

White guava (Psidium guajava L.) fruit juice ameliorated the number of spermatogenic cells in rats (Rattus Novergicus) exposed to lead acetate

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