Lead-induced oxidative stress adversely affects health of the occupational workers

Khan, D A; Qayyum, Shazia; Saleem, Shahid; Fa, Khan

doi:10.1177/0748233708098127

Cited by 106 publications

(86 citation statements)

References 43 publications

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“…However, lead acetate in a dose of 5 mg/kg was not sufficient to induce bilirubin level elevation. Nevertheless, in studies of Mikhail et al (25) and Al-Neamy et al (26) bilirubin levels showed only an insignificant tendency to increase in workers exposed to lead, whereas Khan et al (14) reported that bilirubin concentration was not significantly decreased.…”

Section: Discussionmentioning

confidence: 89%

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The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

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Background: The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear. Therefore, the aim of the study was to explore the association between occupational exposure to lead and nonenzymatic antioxidant concentrations in serum and plasma. Material and Methods: The study population consisted of 278 healthy male employees of lead-zinc plants, with 129 workers classified as having low lead exposure (blood lead level -PbB = 20-39.9 μg/dl) and 149 workers classified as having high lead exposure (PbB = 40-59.8 μg/dl). The control group was composed of 73 healthy male administrative workers. No one from this group had blood lead level or zinc protoporphyrin (ZPP) level greater than normal levels, being 10 μg/dl and 2.5 μg/g of hemoglobin, respectively. In addition to the levels of PbB and ZPP, serum levels of uric acid (UA), albumin, thiol groups of albumin, and bilirubin were determined. The ferric reducing ability of plasma (FRAP) and the plasma level of α-tocopherol were also evaluated. Results: Lead exposure indices were significantly elevated in the examined subgroups as compared with the controls. Serum uric acid levels were significantly elevated in both subgroups, particularly in the group with high exposure. Serum bilirubin concentration was significantly elevated in the group with high exposure compared with the control group, while in the group with low exposure, it showed only a non-significant trend towards an increase. In contrast, ferric-reducing ability of plasma was not significantly greater in the examined subgroups as compared with the control group. Nevertheless, levels of albumin, thiol groups of albumin, and α-tocopherol levels were significantly decreased in the exposed subgroups compared with the control group. Conclusions: Occupational exposure to lead interferes with the blood non-enzymatic antioxidant system. Med Pr 2014;65(4): [443][444][445][446][447][448][449][450][451]

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Section: Discussionmentioning

confidence: 89%

“…Several mechanisms may cause increases in UA levels. High concentrations and long residence time of lead in the renal tubular epithelial cells make kidneys susceptible to lead-induced oxidative stress and inflammation (14). Therefore, hyperuricemia may be due to increased tubular reabsorption or decreased tubular secretion of UA (17,23).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

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“…(18) Three epidemiological studies have demonstrated a positive association between blood lead levels and rate of renal function impairment. (19)(20)(21) Lin et al conducted EDTA mobilisation tests to assess the body burden of lead in patients with different degrees of renal insufficiency and no known lead exposure; their results suggest that long-term, low-level environmental lead exposure may be associated with the progression of renal insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Do people from Taiwan have higher heavy metal levels than those from Western countries?

Liu¹,

Hung

Huang³

et al. 2017

smedj

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INTRODUCTIONSeveral studies have suggested that blood lead and cadmium levels that are well below the current safety standards are associated with health risks, such as peripheral arterial disease, impaired renal function and elevated blood pressure.(1-3) Menke et al reported that blood lead level was significantly associated with myocardial infarction and stroke mortality, even when it was below 0.48 μmol/L (10 μg/dL).(4) A Taiwanese study by Huang reported that seafood contamination was very common in Taiwan, and that the lead and copper levels of the rivers in Taiwan were the highest in the world.(5) The abstract of a study that investigated the concentration of heavy metals in the hair of 700 residents in Taiwan reported that most of the residents exhibited elevated heavy metal levels.(6) However, this abstract is unpublished and only found on the Internet.(6) To the best of our knowledge, there has been no formal report describing the heavy metal levels of healthy subjects in Taiwan. The two reports (5,6) indicate that the finding of elevated heavy metal levels in Taiwanese people might not be unusual. Therefore, for the present study, we hypothesised that there may be greater levels of four common heavy metals (lead, mercury, arsenic and cadmium) in the blood of a Southern Taiwanese population than in Western populations.The most reliable methods for measuring body lead burden are bone X-ray fluorescence studies and calcium disodium ethylenediaminetetraacetic acid (CaNa 2 EDTA) mobilisation tests. This is because blood lead levels only reflect recent exposure to lead (7) and not the lead burden of the body. According to recent reports, body lead burden can be measured by collecting 72-hour urinary lead excretion after intravenous infusion of 1 g of CaNa 2 EDTA.(8,9) These reports recommend the daily collection of urine for 72 hours in a high-volume container before the urine is sent for lead measurement. If most of the lead (or other heavy metal) can be excreted during the first 24 hours after CaNa 2 EDTA infusion, then the level of heavy metal in the urine during the first 24 hours may be reflective of the body burden of these heavy metals. We hypothesised that the level of heavy metal in the urine collected in the first 24 hours would be positively correlated with the body burden of the heavy metal. Thus, the aim of the present study was twofold. First, we aimed to assess the levels of four common heavy metals (lead, mercury, arsenic and cadmium) in the blood of apparently healthy Taiwanese adults and to determine whether these heavy metal levels are greater than those of adults from Western countries. Second, we aimed to test our hypothesis that the level of heavy metal in first-day urine is reflective of the body burden of heavy metals (i.e. most heavy metals are excreted during the first 24 hours). METHODSA total of 40 apparently healthy persons (34 men, six women)

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“…Devedesetih godina prošlog, kao i početkom ovog veka, objavljeno je nekoliko epidemioloških studija u kojima su opisani neželjeni zdravstveni efekti indukovani i na niskoj izloženosti kadmijumu u populacionim grupama u Japanu, Kini, Evropi i SAD. Khan i dr. [8] su zaključili da povišen nivo olova u krvi ima pozitivnu korelaciju sa oksidativnim stresom, zapaljenskim i biohemijskim markerima koji bi mogli da posluže u otkrivanju oštećenja bubrežnih funkcija, pre svega, ali i mnogih drugih, kod profesionalno izložene populacije. Alfridi i dr. [9] su ukazali na, značajno povećanje nivoa olova, kadmijuma i nikla u uzorcima krvi i urina profesionalno izložene grupe radnika čeličane u odnosu na kontrolnu, moguću vezu ovih elemenata sa etiologijom bolesti i potrebu za neposrednim poboljšanjem uslova radne sredine.…”

Section: Uvodunclassified

Toxicological analysis of ambient monitoring in metal industry

Lazarević¹,

Krstić²,

Dimitrijević³

2017

Zas Mat

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Lead-induced oxidative stress adversely affects health of the occupational workers

Cited by 106 publications

References 43 publications

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Do people from Taiwan have higher heavy metal levels than those from Western countries?

Toxicological analysis of ambient monitoring in metal industry

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