While Si and Ge have become detection standards for X-and gamma-ray spectroscopy in the laboratory, their use for an increasing range of applications is becoming marginalized by one or more of their physical limitations; namely the need for ancillary cooling systems or bulky cryogenics, their modest stopping powers and radiation intolerance. Wide band gap compounds offer the ability to operate in a range of chemical, thermal and radiation environments, whilst still maintaining sub-keV spectral resolution at X-ray wavelengths. In addition, these materials encompass such a wide range of physical properties that it is technically feasible to engineer materials to specific applications. However, while compound materials are used routinely in the optical and infrared wavebands, their development at hard X-and gamma-ray wavelengths has been plagued by material and fabrication problems. In this paper we present an overview of suitable materials and review the current progress in producing X-and gamma-ray radiation detectors.