The Huangshaping Pb-Zn-W-Mo polymetallic deposit, located in southern Hunan 9 Province, China, is one of the largest deposits in the region and is unique for its metals 10 combination of Pb-Zn-W-Mo and the occurrence of significant reserves of all these metals. The 11 deposit contains disseminated scheelite and molybdenite within a skarn zone located between 12 Jurassic granitoids and Carboniferous sedimentary carbonate, and sulfide ores located within distal 13 carbonate-hosted stratiform orebodies. The metals and fluids that formed the W-Mo 14 mineralization were derived from granitoids, as indicated by their close spatial and temporal 15 relationships. However, the source of the Pb-Zn mineralization in this deposit remains 16 controversial. 17 Here, we present new sulfur, lead, and strontium isotope data of sulfide minerals (pyrrhotite, 18 sphalerite, galena, and pyrite) from the Pb-Zn mineralization within the deposit, and these data are 19 compared with those of granitoids and sedimentary carbonate in the Huangshaping deposit, 20 thereby providing insights into the genesis of the Pb-Zn mineralization. These data indicate that 21 the sulfide ores from deep levels in the Huangshaping deposit have lower and more consistent 22