Lead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

Abstract

Abstract-++ has a greater action potential duration effect on control conditions. To our knowledge, this is the first work that has developed mathematical models of Pb ++ effect on I CaL current to study its effect on human atrial action potential.

Functional consequences of lead and mercury exposomes in the heart

“…In addition to the humoral and innervation damage promoted by Pb 2+ , this heavy metal may also impact HCN channels, critical for the autonomic triggering of action potentials in the sinoatrial node in the heart. It has been determined that Pb 2+ blocks Cav1.2 channels, but it does carry currents for a prolonged time in ventricular and atrial cells, increasing the risk for arrhythmic events in ventricles and atria (Ferreira de Mattos et al, 2017;Tobón et al, 2017). Experiments performed in-vivo in neonatal rats show that breastfeeding neonatal rats with lead in the milk, enhanced approximately four times the susceptibility of neonates to arrhythmias (Williams et al, 1983).…”