Lead (Pb) exposure promotes diabetes in obese rodents

Tyrrell, Jannifer Beth; Hafida, Samar; Stemmer, Paul M.; Adhami, Angie; Leff, Todd

doi:10.1016/j.jtemb.2016.10.007

Cited by 68 publications

(44 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Jannifer et al . for the first time pressed Pb 2+ exposure in rats to induce impaired lipogenesis with elevated levels of circulating serum triglyceride and thereby introduced its probable implication in the progression of obesity . Following this study, Ting Luo et al .…”

Section: Discussionmentioning

confidence: 90%

“…Thus, a search for newer fundamentals would put across newer diagnostic or therapeutic approaches to handle heavy metal-associated diseases. Jannifer et al for the first time pressed Pb 2+ exposure in rats to induce impaired lipogenesis with elevated levels of circulating serum triglyceride and thereby introduced its probable implication in the progression of obesity [14]. Following this study, Ting Luo et al suggested Pb 2+ exposure to trigger biochemical, transcript-level perturbations in the liver leading to hepatotoxicity [13].…”

Section: Discussionmentioning

confidence: 96%

“…In another study, Pb 2+ at concentrations like 2.20 ppm (10×) and 22.0 ppm (100×) severely influenced the anatomical and physiological vitality of different organs in male rats . While in a recent study Zucker diabetic fatty male rats exposed to 0.05% (w/v) (50 mg·mL −1 ) of lead acetate (PbAc) developed diabetes and obesity . Also, as per CDC 1991, Pb 2+ levels greater than 10 μg·mL −1 is an indication of fatal lead exposure.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Chronic exposure to Pb²⁺ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

et al. 2019

View full text Add to dashboard Cite

Dysregulated hepatic de novo lipogenesis contributes to the pathogenesis of nonalcoholic fatty liver disease in both humans and rodents. Clinical evidence suggests fatty liver to have a positive correlation with serum lead (Pb2+) levels. However, an exact mechanism of Pb2+‐induced fatty liver progression is still unknown. Here, we show that exposure to Pb2+ regulates ChREBP‐dependent hepatic lipogenesis. Presence of Pb2+ ions within the hepatocytes reduces transcript and protein levels of sorcin, a cytosolic adaptor partner of ChREBP. Adenovirus‐mediated overexpression of sorcin in Pb2+ exposed hepatocytes and an in vivo mouse model ameliorates liver steatosis and hepatotoxicity. Hereby, we present Pb2+ exposure to be a lethal disruptor of lipid metabolism in hepatocytes and highlight sorcin as a novel therapeutic target against Pb2+‐induced hepatic dyslipidemia.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

See 1 more Smart Citation

Chronic exposure to Pb²⁺ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Many studies focus on genetic and epigenetic mechanisms of obesity evolution. In the study of Tyrrell et al, Pb-exposed animals showed elevated hepatic triglyceride levels and increased expression of the gluconeogenic genes PEPCK and glucose-6-phosphatase [18]. In cultured rat hepatoma cells, treatment with Pb stimulated PEPCK and glucose-6-phosphatase gene expression, suggesting a possible direct effect of Pb on hepatic gluconeogenic gene expression.…”

Section: Discussionmentioning

confidence: 96%

The Relationship between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead

Matys

Szymańska–Chabowska

Bogunia‐Kubik

et al. 2020

JCM

View full text Add to dashboard Cite

The purpose of this work was to assess the influence of selected CNR1, MC4R, LEP, FTO and VDR FOKI gene polymorphisms on blood and urine concentration markers of lead, cadmium and arsenic in a population directly exposed to these metals. Eighty-five people exposed to lead, arsenic and cadmium were qualified to take part in the study. Standard urine samples and 25 mL of venous blood from each worker were collected to assay basic laboratory and toxicological markers as well as selected single nucleotide polymorphisms (SNPs) within CNR1-cannabinoid receptor 1 gene (rs806368, rs806381, rs1049353, rs12720071), MC4R-melanocortin 4 receptor gene (rs17782313), LEP-leptin promoter gene (rs7799039), FTO-alpha-ketoglutarate-dependent dioxygenase gene (rs9939609) and VDR-vitamin D receptor (rs10735810) genes. It appeared that, except for the MC4R SNP, all the other polymorphisms were found to be associated with various laboratory parameters. Arsenic concentration in urine was associated with all four CNR1 and LEP SNPs, while cadmium concentration in blood was affected by the VDR polymorphism. Moreover, some significant relationships were also observed between CNR1 rs1049353 and FTO rs9939609 gene variants and markers of lead exposure. These results imply SNPs within genes coding for proteins involved in development of metabolic syndrome may be of prognostic value for persons directly exposed to lead, cadmium and arsenic.

show abstract

“…Tyrrell et al . 34 treated rats with 0.05% w/v Pb acetate in their drinking water for 8 weeks and found that the rats developed induced fasting hyperglycaemia 34 . Elements that have entered into organisms can also be biotransformed to other compounds, with resulting changes in toxicity.…”

Section: Introductionmentioning

confidence: 99%

Tracing heavy metals in ‘swine manure - maggot - chicken’ production chain

Wang

Zhang

Wang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

With the development of large-scale livestock farming, manure pollution has drawn much attention. Conversion by insects is a rapid and cost-effective new method for manure management. Swine manure conversion with maggots (Musca domestica larvae) has developed, and the harvested maggots are often used as animal feed. However, the flow of heavy metals from manure to downstream processes cannot be ignored, and therefore, heavy metal content was measured in untreated raw manure, maggot-treated manure, harvested maggots and maggot-eating chickens (chest muscle and liver) to evaluate potential heavy metal risks. The levels of zinc, copper, chromium, selenium, cadmium and lead had significant differences between untreated raw manure and maggot-treated manure. The concentrations of all detected heavy metals, except for cadmium and selenium, in maggots met the limits established by the feed or feed additive standards of many countries. The bioaccumulation factor (BAF) of heavy metals decreased with the increase of the maggot instar, indicating that heavy metals were discharged from the bodies of maggots with the growth of maggots. Also, the contents of overall heavy metals in chickens fed harvested maggots met the standards for food. In conclusion, regarding heavy metals, it is eco-safe to use maggots in manure management.

show abstract

Lead (Pb) exposure promotes diabetes in obese rodents

Cited by 68 publications

References 14 publications

Chronic exposure to Pb²⁺ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

Chronic exposure to Pb²⁺ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

The Relationship between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead

Tracing heavy metals in ‘swine manure - maggot - chicken’ production chain

Contact Info

Product

Resources

About

Lead (Pb) exposure promotes diabetes in obese rodents

Cited by 68 publications

References 14 publications

Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

The Relationship between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead

Tracing heavy metals in ‘swine manure - maggot - chicken’ production chain

Contact Info

Product

Resources

About

Chronic exposure to Pb²⁺ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

Chronic exposure to Pb²⁺ perturbs ChREBP transactivation and coerces hepatic dyslipidemia