Lead (Pb) induced Oxidative Stress as a Mechanism to Cause Neurotoxicity in Drosophila melanogaster

Olakkaran, Shilpa; Anupama, Kizhakke Purayil; Antony, Anet; Gurushankara, Hunasanahally Puttaswamygowda

doi:10.1016/j.tox.2021.152959

Cited by 36 publications

(17 citation statements)

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“…Transport of essential metals into the cells and organelles, where they exert a role as signaling agents or cofactors and, in particular, as activators or redox system components, has been previously reported [ 30 , 31 ]. Several studies indeed demonstrated that reactive oxygen species (ROS) production and oxidative stress play a key role in the toxicity and carcinogenicity of metals such as As [ 32 ], Cd [ 33 ], Cr [ 34 ], Pb [ 35 ], and Hg [ 36 ]. Alongside oxidative stress, however, the role of Pb-induced epigenetic modifications in eliciting CNS degeneration is becoming increasingly evident [ 15 ], and it is plausible that the two mechanisms may coexist.…”

Section: Toxic Metals As Risk Factors For Ndmentioning

confidence: 99%

Neuron Protection by EDTA May Explain the Successful Outcomes of Toxic Metal Chelation Therapy in Neurodegenerative Diseases

Ferrero

2022

Biomedicines

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Many mechanisms have been related to the etiopathogenesis of neurodegenerative diseases (NDs) such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease. In this context, the detrimental role of environmental agents has also been highlighted. Studies focused on the role of toxic metals in the pathogenesis of ND demonstrate the efficacy of treatment with the chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA) in eliminating toxic metal burden in all ND patients, improving their symptoms. Lead, cadmium, aluminum, nickel, and mercury were the most important toxic metals detected in these patients. Here, I provide an updated review on the damage to neurons promoted by toxic metals and on the impact of EDTA chelation therapy in ND patients, along with the clinical description of a representative case.

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Section: Toxic Metals As Risk Factors For Ndmentioning

confidence: 99%

Neuron Protection by EDTA May Explain the Successful Outcomes of Toxic Metal Chelation Therapy in Neurodegenerative Diseases

Ferrero

2022

Biomedicines

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“…The toxicity of heavy metals occurs because of the replacement of the divalent cations (Fe 2+, Mg 2+, Ca 2+) with monovalent (Na + ), which interfere with cell biological metabolism. Pb 2+ can displace Ca, affecting protein kinase C, which regulates nerve excitation and memory storage [17]- [19]. The wastewater that is not treated correctly has the potential to cause a decrease in the quality of aquatic ecosystems and public health [20]- [22].…”

Section: Introductionmentioning

confidence: 99%

Heavy metals assessment of hospital wastewater during COVID-19 pandemic

Sakina

Sodri²,

Kusnoputranto³

2023

IJPHS

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Hospital wastewater contains heavy metals that threaten environmental and human health through bioaccumulation and biomagnification. Each heavy metal contributes a different impact on human health and the environment. Monitoring the heavy metals in wastewater is essential to prevent those severe impacts. However, it is still rare for a study to assess heavy metals obtained from the discharge of hospital wastewater in Indonesia. Therefore, this study investigated 14 parameters of heavy metals in hospital wastewater. We tested wastewater quality from September 2021 to February 2022, with SNI 6989-59-2008 sampling methods with 14 parameters. Results show that over 14 parameters are still below the threshold value and other previous studies. It might be because the biological treatment used in the hospital wastewater treatment plant (HWWTP) reduces these micropollutants efficiently. The fluidized bed biofilm reactor (FBBR) system is an aerobic process with microorganisms attached to the bio-green. This technique is to form suspensions of solid particles in sparse media with gas streams for chemical or physical processes. The sewage discharge reveals the occurrence of heavy metals in hospital wastewater, even though it does not reveal a high concentration due to the effectiveness of the FBBR system in HWWTP.

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“…Lead could electrostatically form a complex with SOD, enter the active channel of SOD, and change its secondary structure, resulting in the release of Cu 2+ and Zn 2+ from the active site of SOD, which led to the decrease of enzyme activity (Zhang et al, 2014). Lead accumulation in the Drosophila brain induced oxidative stress by generating ROS and lipid peroxidation (LPO), depleting SOD and CAT (Shilpa et al, 2021). It has also been shown that pre‐ and neonatal lead exposure in rats disrupts antioxidant activity and downregulates its messenger RNA (mRNA) and enzyme expression in the hippocampus (Baranowska‐Bosiacka et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies investigated the mechanism of lead induced neurotoxicity by observing the changes of SOD or CAT in the brain of lead treated Drosophila and its role in protecting from lead neurotoxicity (Shilpa et al, 2021), also was investigated and compared SOD activity inhibited in lead treated zebrafish livers and explored the mechanism of SOD inactivation by lead at the molecular level (Zhang et al, 2014). However, lead effected on mite and SOD were not well known.…”

Section: Introductionmentioning

confidence: 99%

Regulation of three subtypes of SOD gene in Aleuroglyphus ovatus (Acari:Acaridae) under lead stress

Ai,

Xiong,

Zhu

et al. 2023

Arch Insect Biochem Physiol

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Superoxide dismutase (SOD) is an important enzyme that acts as the first line of protection in the mite antioxidant defense system, involved in eliminating reactive oxygen species (ROS) under harsh environmental conditions. Nevertheless, the SOD gene family was yet to be reported in stored grain pest mite (Aleuroglyphus ovatus). In this study, A. ovatus was used to evaluate the response of SOD gene during lead stress. A. ovatus were separately exposed to different concentration lead (12.5, 25, 50, and 100 mg/kg), which induce the dynamic trend of SOD enzyme activity initially increased and then reduced with an increase in lead concentration, whereas they were still substantially higher than the control group. Moreover, after lead stress, it was found that all of the three SOD genes showed enhanced relative messenger RNA expression at high concentrations and decreased relative expression at low concentrations, which indicated that lead stress induces the expression of AoSODs. The present work implies that AoSODs play an important role in resisting oxidative damage caused by lead stress.

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Lead (Pb) induced Oxidative Stress as a Mechanism to Cause Neurotoxicity in Drosophila melanogaster

Cited by 36 publications

References 100 publications

Neuron Protection by EDTA May Explain the Successful Outcomes of Toxic Metal Chelation Therapy in Neurodegenerative Diseases

Neuron Protection by EDTA May Explain the Successful Outcomes of Toxic Metal Chelation Therapy in Neurodegenerative Diseases

Heavy metals assessment of hospital wastewater during COVID-19 pandemic

Regulation of three subtypes of SOD gene in Aleuroglyphus ovatus (Acari:Acaridae) under lead stress

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