Lead Poisoning and Head Absorption

Legge, Thomas; Goadby, Kenneth W.

doi:10.1097/00005053-191304000-00019

Cited by 21 publications

(16 citation statements)

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“…These findings are consistent with numerous studies in animals and in man (6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Discussionsupporting

confidence: 93%

Deaths from chronic renal disease in U.S. battery and lead production workers.

Cooper¹

1988

Environ Health Perspect

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This report is based on an analysis of deaths in 4519 battery plant workers and 2300 lead production or smelter workers during the years 1947 to 1980. Causes were coded to the seventh (1955) revision of the International Classification of Diseases. There were significant excess deaths for "other hypertensive disease" (444-447) and "chronic nephritis" (592-594) in both cohorts, the standardized mortality ratios (SMRs) being 320 and 475, respectively, for the former causes and 222 and 265 for the latter. Proportionate mortality analysis, which adjusted for race, also showed elevated ratios, 241 and 388 for the former causes and 296 and 186 for the latter. Deaths from other hypertension-related diseases did not show comparable excesses. Renal cancer deaths were fewer than expected, SMRs being 41 and 74, respectively.

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“…These findings are consistent with numerous studies in animals and in man (6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Discussionsupporting

confidence: 93%

Deaths from chronic renal disease in U.S. battery and lead production workers.

Cooper¹

1988

Environ Health Perspect

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“…There also is evidence that with closely spaced multiple pregnancies, maternal blood lead levels in subsequent pregnancies are lower and the increases in maternal blood lead occurring during late pregnancy and lactation are lower rela tive to those in the first pregnancy ). This observation is consonant with observations from the lead industry in the nineteenth and early twentieth century (Legge 1901;Legge and Goadby 1912;Paul 1860), which held that if a lead-poisoned woman had a child, her symptoms would be assuaged. This limited evidence suggests that the greatest concern about lead exposure may be during the first pregnancy, although this observation is probably meaningful only at very high lead levels.…”

Section: Mobilization Of Endogenous Bone Lead In Pregnancysupporting

confidence: 80%

Chronic Ayurvedic medicine use associated with major and fatal congenital abnormalities

Wong

Dargan

Koutsogiannis

et al. 2015

Medical Journal of Australia

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“…Renal effects in man have been described in clinical reports (21,24,35), by studies of renal function (14,23,33,38,47), and by epidemiologic studies. For example, Lane (19,20) Because, as Lane (19) pointed out, animals exposed to lead have shown both tubular and vascular changes in the kidneys, it is of interest that in our study there were excess deaths in both the chronic nephritis and the renal vascular disease categories.…”

Section: Chronic Renal Diseasementioning

confidence: 99%

Mortality among employees of lead battery plants and lead-producing plants, 1947-1980.

Cooper¹,

Wong²,

Kheifets³

1985

Scand J Work Environ Health

121

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Mortality among employees of lead battery plants and lead-producing plants, . Scand J Work En viron Health II (1985) 331-345. Two cohorts of male lead workers, 4 519 battery plant workers and 2 300 lead production workers, all of whom had been employed for at least one year during the period I January 1946 through 31 December 1970, were observed for mortality during the 34 years from 1 Januar y 1947 through 31 December 1980. Vital status as of the closing date was determined for 94.7 lifo of the former group and 91.6 lifo of the latter. There were 1 718 deaths in the first cohort and 621 in the second. Mortality from all causes combined was significantly greater than expected in each cohort, the standardized mortality ratio (SMR) being 107 and 113, respectively. Among the battery plant workers the greater than expected mortality rate resulted in large part from a significant number of excess deaths from malignant neoplasms (SMR 113), other hypertensive disease (mainly renal) (SMR 320), chronic nephritis (SMR 222), and a group of ill-defined conditions (SMR 355). Among the lead production workers the pattern was similar, with a significant number of excess deaths from other hypertensive disease (SMR 475), hypertensive heart disease (SMR 203), chronic nephritis (SMR 265), and ill-defined conditions (SMR 214). There was also a significant excess of deaths from external causes (SMR 143). The SMR for total malignancies was 113, but this value was not significantly elevated at the 5 % level. In neither cohort were deaths from cerebrovascular disease in significant excess, the SMR being 93 and 132, respectively. A proport ionate mortality analysis showed that the excess deaths from cerebrovascular diseaseand from hypertensive heart disease among smelter workers were in part due to the high proportion of nonwhites in the smelter populations. The stomach, liver, and lungs were the sites responsible for most excess cancer deaths in both cohorts, but the elevated SMR values were statistically significant only for gastric and lung cancers in battery plant workers. There were no excess deaths from malignancies of the kidney, brain, or Iymphopoeitic system in either cohort. It is impossible to relate the observed mortality to levels of lead exposure; because of meager quantit ative information prior to 1960. It is known that past exposures had been very high. Ethnicity, diet, alcohol, and cigarette smoking could not be ruled out as possibleconfounding etiologic factors for the cancer deaths.

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Lead Poisoning and Head Absorption

Cited by 21 publications

References 0 publications

Deaths from chronic renal disease in U.S. battery and lead production workers.

Deaths from chronic renal disease in U.S. battery and lead production workers.

Chronic Ayurvedic medicine use associated with major and fatal congenital abnormalities

Mortality among employees of lead battery plants and lead-producing plants, 1947-1980.

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