The reality of women in political leadership is constructed by the mass media, which is then conveyed to the public. Often, the media places women as sexual objects that focus on body shape. On the other hand, the media has the power to influence public opinion, which raises the question of how the media sees women in dealing with crises. Moreover, the COVID-19 pandemic has become a challenge for leaders globally, including women leaders in Indonesia. For this reason, this study focuses on the framing of the handling of COVID-19 by female regional leaders in the Detik.com media in the period March 2, 2020 -September 30, 2021. This study seeks to find out how the framing of female regional leaders in handling COVID-19 in the Detik.com media. The aim is to see how Detik.com media frames women regional leaders in handling COVID-19. This study used a qualitative approach to reality construction and framing theory. Meanwhile, the method employed framing with the analytical model of Zhongdang Pan and Gerald M. Kosicki. The research analysis technique utilized four basic structures: syntax, script, thematic, and rhetorical. For validity, triangulation of data sources was used by comparing the findings from Detik.com with other sources, such as books, journals, the internet, and others. The study results revealed that the framing of female regional leaders by Detik.com contained gender stereotypes and marginalization. In addition, this study also found that women's feminine traits were useful in handling COVID-19. The significance of the research is to show the reality of the media as a result of selection, construction, and reconstruction so that the public must be more critical in receiving information.